R2530

罗匹尼罗 盐酸盐

powder, ≥98% (HPLC)

• 别名: 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride, SKF 101468 hydrochloride
• 经验公式（希尔记法）: C₁₆H₂₄N₂O · HCl
• CAS号: 91374-20-8
• 分子量: 296.84
• MDL號碼: MFCD01754173
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329824018
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: light yellow
• 溶解度: H₂O: >10 mg/mL
• 起源: GlaxoSmithKline
• SMILES 字串: Cl.CCCN(CCC)CCc1cccc2NC(=O)Cc12
• InChI: 1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
• InChI 密鑰: XDXHAEQXIBQUEZ-UHFFFAOYSA-N
• 基因資訊: human ... DRD2(1813) , DRD3(1814) , DRD4(1815)

说明

生化／生理作用

An agonist at the D₂ and D₃ dopamine receptor subtypes, binding with higher affinity to D₃ than to D₂ or D₄. It has negligible effect on D₁-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT₁, 5-HT₂, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.

Ropinirole hydrochloride is effectively used to treat early and late Parkinson′s disease.

特點和優勢

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H302,H400
• 防範說明: P264 - P270 - P273 - P301 + P312 - P391 - P501
• 危險分類: Acute Tox. 4 Oral - Aquatic Acute 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves