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R2500

Sigma-Aldrich

全反式视黄醛

powder, ≥98%

别名:

维生素 A 醛

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About This Item

经验公式（希尔记法）:
C20H28O
CAS号:
116-31-4
分子量:
284.44
MDL號碼:
MFCD00001550
分類程式碼代碼:
12352205
PubChem物質ID:
24899355
NACRES:
NA.79
价格与库存信息目前不能提供

生物源

synthetic (organic)

品質等級

200

化驗

≥98%

形狀

powder

技術

HPLC: suitable

顏色

yellow

mp

62-64 °C

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H]C(=O)\C=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C

InChI

1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

InChI 密鑰

NCYCYZXNIZJOKI-OVSJKPMPSA-N

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相关类别

一般說明

全反式视黄醛是维生素A族的主要衍生物之一。各种食物都是维生素A的来源。它主要存在于肝脏和颜色鲜艳的蔬菜中。[1]

應用

全反式视黄醛已被用于：
  • 光遗传学实验[2]
  • 电生理学实验[3]
  • 研究AKR1B10（醛酮还原酶（AKR）超家族成员）对气道上皮细胞的视黄醛转化为视黄醇的影响[4]
  • 人子宫内膜基质细胞的蜕膜化[5]

生化／生理作用

全反式视黄醛在体内可通过视黄醛脱氢酶作用转化为视黄酸。视黄酸是视黄酸受体 (RAR) 和类视色素 X 受体 (RXR) 的配体，这两种受体作为转录因子调控正常和恶性细胞的生长和分化。在可视和非可视系统中，视黄醛异构体也是发色团，可与 G-蛋白偶联跨膜蛋白家族的视蛋白结合，形成光敏受体。全反式视黄醛是一种强效的光敏剂。

包裝

密封安瓿瓶。

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000413912
0000413910
0000413909
0000409390
0000409392

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Slide 1 of 4

1 of 4

维甲酸 United States Pharmacopeia (USP) Reference Standard

USP

1674004

维甲酸

维甲酸 European Pharmacopoeia (EP) Reference Standard

T1850000

维甲酸

维生素A标准液 溶液 100 μg/mL ± 25% (Refer to COA) (Ethanol with 0.1% (w/v) BHT), ampule of 1 mL, reference material, Cerilliant®

Supelco

V-011

维生素A标准液 溶液

视黄醇乙酸酯 synthetic, crystalline solid or supercooled liquid

Sigma-Aldrich

R4632

视黄醇乙酸酯

Jihye Yeon et al.
PLoS biology, 16(6), e2004929-e2004929 (2018-06-09)
Animal locomotion is mediated by a sensory system referred to as proprioception. Defects in the proprioceptive coordination of locomotion result in uncontrolled and inefficient movements. However, the molecular mechanisms underlying proprioception are not fully understood. Here, we identify two transient
Yasushi Imamoto et al.
Biochimica et biophysica acta, 1837(5), 664-673 (2013-09-12)
Cone visual pigments are visual opsins that are present in vertebrate cone photoreceptor cells and act as photoreceptor molecules responsible for photopic vision. Like the rod visual pigment rhodopsin, which is responsible for scotopic vision, cone visual pigments contain the
Smoking-induced upregulation of AKR1B10 expression in the airway epithelium of healthy individuals
Wang R, et al.
Chest, 138(6), 1402-1410 (2010)
Hai Li et al.
The Journal of biological chemistry, 291(49), 25319-25325 (2016-10-30)
Natural anion channelrhodopsins (ACRs) recently discovered in cryptophyte algae are the most active rhodopsin channels known. They are of interest both because of their unique natural function of light-gated chloride conductance and because of their unprecedented efficiency of membrane hyperpolarization
Juan Antonio Sánchez-Alcañiz et al.
Nature communications, 9(1), 4252-4252 (2018-10-14)
Through analysis of the Drosophila ionotropic receptors (IRs), a family of variant ionotropic glutamate receptors, we reveal that most IRs are expressed in peripheral neuron populations in diverse gustatory organs in larvae and adults. We characterise IR56d, which defines two
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Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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