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Merck
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Q2876

Sigma-Aldrich

喹吖因氮芥 二盐酸盐

≥85% (HPLC)

别名:

氮芥喹丫因 二盐酸盐, 氮芥喹丫因 二盐酸盐 二盐酸盐

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About This Item

经验公式（希尔记法）:
C23H28Cl3N3O · 2HCl
CAS号:
4213-45-0
分子量:
541.77
Beilstein:
3819822
EC 号:
224-140-9
MDL编号:
MFCD00043254
UNSPSC代码:
12352101
PubChem化学物质编号:
24899329
NACRES:
NA.32

方案

≥85% (HPLC)

储存温度

−20°C

SMILES字符串

Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NC(C)CCCN(CCCl)CCCl)c2c1

InChI

1S/C23H28Cl3N3O.2ClH/c1-16(4-3-11-29(12-9-24)13-10-25)27-23-19-7-5-17(26)14-22(19)28-21-8-6-18(30-2)15-20(21)23;;/h5-8,14-16H,3-4,9-13H2,1-2H3,(H,27,28);2*1H

InChI key

JETDZFFCRPFPDH-UHFFFAOYSA-N

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一般描述

氮芥喹丫因（Quinacrine mustard dihydrochloride） 是一种荧光吖啶染料，简称QM。在水溶液中，氯乙基迅速失去氯离子，产生氮丙啶阳离子。这些阳离子很容易与蛋白质和核酸的羧基、硫醇和杂环氮基团或其他亲核试剂发生反应。

应用

氮芥喹丫因（Quinacrine mustard dihydrochloride）用于染色中期染色体。最新应用包括玉米的 Q 带分析和鱼类的核型分析。该染料还用作锥虫的活体染色剂。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBD3811V
SLCD2226
SLCB7796
SLBX8180
SLBT9169

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D Fukushi et al.
Cytogenetics and cell genetics, 92(3-4), 254-263 (2001-07-04)
The DNA of Apodemus argenteus was digested with DraI, and the resultant DraI fragment of highly repetitive DNA was isolated and analyzed by DNA filter hybridization, cloning, sequencing, and fluorescence in situ hybridization (FISH). Southern blot hybridization and nucleotide sequencing
N Ye et al.
Mutation research, 435(1), 43-61 (1999-10-20)
An adaptive response, low doses of a mutagen rendering cells more able to subsequently cope with higher doses of that or a related challenging mutagen, enhances nucleotide excision repair in human fibroblasts. After fibroblasts were flashed with 20 J/m2 of
Yong Yu et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(7), 3907-3912 (2003-03-20)
Noncompetitive inhibitors of the nicotinic acetylcholine (ACh) receptors suppress cation flux directly by binding in and blocking the open channel or indirectly by stabilizing closed states of the receptor. The lidocaine derivative QX-314 and the acridine derivative quinacrine act directly
M Robinson et al.
British journal of haematology, 108(4), 859-864 (2000-05-03)
Animal in vivo biotinylation studies have demonstrated that thiazole orange (TO) labels the youngest cells in the circulation. TO has since been widely used for the measurement of reticulated platelets. As recent findings suggest that at high concentrations TO also
Michiko Inuma et al.
Zoological science, 24(6), 588-595 (2007-09-18)
"Delayed QM-fluorescence" refers to the unusual kinetics of fluorescence from most of the C-heterochromatic regions of the chromosomes of the small Japanese field mouse Apodemus argenteus. When stained with quinacrine mustard (QM-stained), these C-heterochromatic regions emit weak fluorescence immediately after
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