推荐产品
生物来源
microbial
质量水平
方案
~99%
表单
(powderor powder with lumps)
mp
153-155 °C (lit.)
溶解性
water: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
储存温度
2-8°C
SMILES字符串
N.SC(=S)N1CCCC1
InChI
1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
InChI key
MDDIUTVUBYEEEM-UHFFFAOYSA-N
基因信息
human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846) , RELA(5970)
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相关类别
一般描述
吡咯烷二硫代甲酸铵盐是一种核因子κB (NF-κB)抑制剂。它作为一种螯合剂,可以从溶液中预浓缩痕量金属。吡咯烷二硫代甲酸铵盐(PDTC)具有抗氧化性质。它能抑制淋巴细胞、神经元和血管内皮细胞的凋亡。
应用
吡咯烷二硫代甲酸铵盐已被用于:
消除人脑细胞中microRNA-146a启动子荧光素酶报告基因活性
- 抑制人单核细胞中的核因子κB(NF-κB)动员和TNF(肿瘤坏死因子)产生
- 降低大鼠的中性粒细胞活性
- 防止阿霉素(ADR)处理的足细胞的Ca2+内流
消除人脑细胞中microRNA-146a启动子荧光素酶报告基因活性
生化/生理作用
通过抑制 NOS mRNA 的翻译从而阻止一氧化氮合成酶的诱导;引发大鼠平滑肌细胞中的细胞凋亡并抑制白血病 HL-60 细胞中的细胞凋亡。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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