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质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
protect from light
颜色
off-white to gray-pink
溶解性
DMSO: >10 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
N(CCCc2ccccc2)c1c(cc(cc1)C)N
InChI
1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
InChI key
YMFNPBSZFWXMAD-UHFFFAOYSA-N
应用
JSH-23 已被用作一种核因子 κB（NF-κB）p65 抑制剂。
生化/生理作用
JSH-23 是一种 NF-κB 核易位抑制剂。
JSH-23 是一种 NF-κB 核易位抑制剂。EMSA 和蛋白质印迹分析表明，它抑制 LPS 和细胞因子诱导的 NF-kB p65 亚基的核易位过程。该化合物具有适度的抑制活性（RAW 264.7 细胞中 IC50 值为 7.1 uM），但不影响 IkB 降解或恢复。该化合物以剂量依赖性方式抑制 LPS 诱导的细胞因子、COX2 和 iNOS 的表达，并且可能结合或干扰 p65 的和定位信号（NLS）。
其他说明
光和空气敏感。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
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