所有图片(2)
About This Item
经验公式（希尔记法）:
C15H16O6
CAS号:
分子量:
292.28
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.77
推荐产品
形狀
powder
品質等級
SMILES 字串
[H][C@@]12OC(=O)[C@]([H])([C@@H]1C(C)=C)[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@@]2([H])[C@]35C
InChI
1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8+,9-,10-,13-,14-,15+/m1/s1
InChI 密鑰
PIMZUZSSNYHVCU-KBLUICEQSA-N
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一般說明
Picrotoxinin is a component of picrotoxin and can be derived from plants. It is a non-nitrogenous compound.
應用
Picrotoxinin has been used as an agonist of taste 2 receptor member 14 (TAS2R14) to perform an array-based bitter receptor screening assay and to study the effect of calcium buffering and calcium sensor type on its sensitivity.
生化／生理作用
Picrotoxinin acts as a potent convulsant.
GABAA 受体拮抗剂；与受体连接的Cl−通道结合。
特點和優勢
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glycine Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
其他說明
Active component of picrotoxin
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 2 Oral
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Shelley H Huang et al.
European journal of pharmacology, 494(2-3), 131-138 (2004-06-24)
Ginkgolides A, B, and C are diterpene trilactones and active constituents of the 50:1 Ginkgo biloba leaf extract widely used in the symptomatic treatment of mild to moderate dementia. Using the two-electrode voltage clamp methodology, these ginkgolides were found to
Xiu-Lian Ju et al.
Chemosphere, 69(6), 864-871 (2007-08-07)
A number of widely diverse compounds that show inhibitory activities at the picrotoxinin binding sites in housefly and rat GABA receptors were investigated by using the distance comparison technique (DISCOtech) and comparative molecular field analysis (CoMFA) methods to explore the
Y Eguchi et al.
Insect molecular biology, 15(6), 773-783 (2007-01-05)
Ligand-gated chloride channels (LGICs) are important targets for insecticides and parasiticides. Genes encoding subunits of two LGICs, a glutamate-gated chloride channel (MdGluCl-alpha) and a gamma-aminobutyric acid (GABA)-gated chloride channel (MdRdl), were cloned from house-flies (Musca domestica L.). These genes were
J Baufreton et al.
Journal of neurophysiology, 86(1), 75-85 (2001-06-30)
The subthalamic nucleus (STN) influences the output of the basal ganglia, thereby interfering with motor behavior. The main inputs to the STN are GABAergic. We characterized the GABA(A) receptors expressed in the STN and investigated the response of subthalamic neurons
Herbal products and GABA receptors
Johnston GAR
Encyclopedia of Neuroscience, 4, 1095-1101 (2009)
商品
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