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About This Item
经验公式（希尔记法）:
C12H11NO
CAS号:
分子量:
185.22
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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一般說明
吡非尼酮（5-甲基-1-苯基-2-[1H]-吡啶酮）是合成的吡啶 衍生物。
應用
吡非尼酮用于：
- 作为兔的术后滴眼剂，分析其抗纤维化作用，改进青光眼滤过手术
- 作为抗瘢痕形成剂，检查其是否影响兔植入青光眼引流装置（GDD）后的异物反应
- 在人眼眶成纤维细胞（hOF）原代培养物中测试其抗纤维化潜力
- 作为肿瘤坏死因子（TNFα）抑制剂，研究其在缺氧中的作用
生化／生理作用
吡非尼酮可抑制胶原生成和成纤维细胞增殖。在多种肺纤维化动物模型和临床试验中显示出抗纤维化和抗炎属性。
吡非尼酮用于治疗特发性肺纤维化（IPF）。有助于减少肺功能下降引起的衰弱，延长无进展生存期。吡非尼酮可抑制人Tenon′s 囊成纤维细胞胶原蛋白的增殖和收缩。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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