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Merck

SML1954

Sigma-Aldrich

X-34

≥90% (HPLC), powder, amyloid-specific fluorescent dye

别名:

1,4-双(3-羧基-4-羟基苯基乙烯基)苯

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About This Item

经验公式(希尔记法):
C24H18O6
分子量:
402.40
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77

产品名称

X-34, ≥90% (HPLC)

质量水平

方案

≥90% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2.0 mg/mL, clear

储存温度

2-8°C

SMILES字符串

OC(C=C1)=C(C(O)=O)C=C1C=CC2=CC=C(C=CC3=CC=C(O)C(C(O)=O)=C3)C=C2

InChI

1S/C24H18O6/c25-21-11-9-17(13-19(21)23(27)28)7-5-15-1-2-16(4-3-15)6-8-18-10-12-22(26)20(14-18)24(29)30/h1-14,25-26H,(H,27,28)(H,29,30)

InChI key

MCBNOAYTZBUCSX-UHFFFAOYSA-N

生化/生理作用

X-34是一种荧光淀粉样特异性染料。 它与Pittsburgh CompoundB的结合位点不同,并且是β-折叠结构的一种高度荧光标记。
X-34(1,4-双(3-羧基-4-羟基苯基乙烯基)-苯)是参与到降低Aβ42水平(淀粉样-β肽的42个残基异构体)的一种小分子γ-分泌酶调节因子(GSM)。X-34还被用于在活的转基因秀丽隐杆线虫体内对具有经典淀粉样纤维超微结构的细胞内免疫反应性沉积物进行可视化。它还可作为组织化学染色剂用于确定阿尔茨海默氏′病(AD)的病理变化。
荧光淀粉样特异性染料

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34
Link CD
Neurobiology of Aging, 22, 217-226 (2001)
Taweesak Tangrodchanapong et al.
Molecules (Basel, Switzerland), 26(8) (2021-05-01)
The pathological finding of amyloid-β (Aβ) aggregates is thought to be a leading cause of untreated Alzheimer's disease (AD). In this study, we isolated 2-butoxytetrahydrofuran (2-BTHF), a small cyclic ether, from Holothuria scabra and demonstrated its therapeutic potential against AD
Andy P Tsai et al.
Neurobiology of disease, 153, 105303-105303 (2021-02-26)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, robust microgliosis, neuroinflammation, and neuronal loss. Genome-wide association studies recently highlighted a prominent role for microglia in late-onset AD (LOAD). Specifically, inositol polyphosphate-5-phosphatase (INPP5D), also known as SHIP1
Marcus Bäck et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 22(51), 18335-18338 (2016-11-04)
Deposits comprised of amyloid-β (Aβ) are one of the pathological hallmarks of Alzheimer's disease (AD) and small hydrophobic ligands targeting these aggregated species are used clinically for the diagnosis of AD. Herein, we observed that anionic oligothiophenes efficiently displaced X-34
Substrate-targeting ?-secretase modulators
Kukar TL
Nature, 453, 925-929 (2008)

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