P0778

Pindolol

≥98% (TLC), powder

• 别名: 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
• 经验公式（希尔记法）: C₁₄H₂₀N₂O₂
• CAS号: 13523-86-9
• 分子量: 248.32
• EC號碼: 236-867-9
• MDL號碼: MFCD00010530
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24277795
• NACRES: NA.77

属性

• 品質等級: 200
• 化驗: ≥98% (TLC)
• 形狀: powder
• 顏色: white to off-white
• mp: 167-171 °C (lit.)
• 溶解度: 0.1 M NaOH: 0.2 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL; 0.1 M HCl: 20 mg/mL; acetic acid: 50 mg/mL; H₂O: insoluble
• 起源: Novartis
• 儲存溫度: 2-8°C
• SMILES 字串: CC(C)NCC(O)COc1cccc2[nH]ccc12
• InChI: 1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
• InChI 密鑰: JZQKKSLKJUAGIC-UHFFFAOYSA-N
• 基因資訊: human ... ADRB1(153) , ADRB2(154) , HTR1A(3350)

说明

應用

Pindolol has been used in intestinal transport and metabolism assays[1] and cassette mix preparation.[2]

生化／生理作用

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.[3]

β₁-adrenoceptor antagonist; putative 5-HT_1A serotonin receptor agonist; vasodilator.

特點和優勢

Shelf-life of the powder is at least five years.

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H315,H319,H335
• 防範說明: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves