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Merck

P0052

Sigma-Aldrich

PNU-74654

≥98% (HPLC), solid

别名:

苯甲酸,2-苯氧基-,2-[(5-甲基-2-呋喃基)亚甲基]酰胺

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About This Item

经验公式(希尔记法):
C19H16N2O3
分子量:
320.34
MDL號碼:
分類程式碼代碼:
12352203
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

solid

顏色

white to off-white

溶解度

DMSO: >10 mg/mL

儲存溫度

2-8°C

SMILES 字串

Cc1ccc(\C=N\NC(=O)c2ccccc2Oc3ccccc3)o1

InChI

1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+

InChI 密鑰

JJEDWBQZCRESJL-DEDYPNTBSA-N

應用

PNU-74654已被:
  • 作为β-连环蛋白信号转导抑制剂,研究对乌贼胚漏斗软骨分化的影响
  • 作为Wnt信号抑制剂,研究其对前列腺癌细胞系糖原合成酶激酶3 (GSK-3)的抑制作用
  • 作为Wnt信号通路抑制剂,研究其对瘦素诱导的乳腺癌细胞增殖的影响

生化/生理作用

PNU-74654 通过阻断 β-连环蛋白和 TCF(T 细胞因子)抑制 Wnt-β。PNU-74654 也是一种抗肿瘤药物。Wnt /β-catenin通路(经典通路)的异常激活通过β-catenin和T细胞因子(TCF)之间的相互作用参与驱动不同肿瘤(如结肠癌)的发生/发展,T细胞因子分解细胞增殖和分化中靶基因的表达。在癌细胞系中抑制该通路活性可有效阻断其生长。PNU-74654通过抑制β-catenin和TCF之间的相互作用抑制该通路。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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