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About This Item
经验公式（希尔记法）:
C19H16N2O3
CAS号:
分子量:
320.34
MDL號碼:
分類程式碼代碼:
12352203
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
white to off-white
溶解度
DMSO: >10 mg/mL
儲存溫度
2-8°C
SMILES 字串
Cc1ccc(\C=N\NC(=O)c2ccccc2Oc3ccccc3)o1
InChI
1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+
InChI 密鑰
JJEDWBQZCRESJL-DEDYPNTBSA-N
應用
PNU-74654已被：
- 作为β-连环蛋白信号转导抑制剂，研究对乌贼胚漏斗软骨分化的影响
- 作为Wnt信号抑制剂，研究其对前列腺癌细胞系糖原合成酶激酶3 (GSK-3)的抑制作用
- 作为Wnt信号通路抑制剂，研究其对瘦素诱导的乳腺癌细胞增殖的影响
生化／生理作用
PNU-74654 通过阻断 β-连环蛋白和 TCF（T 细胞因子）抑制 Wnt-β。PNU-74654 也是一种抗肿瘤药物。Wnt /β-catenin通路（经典通路）的异常激活通过β-catenin和T细胞因子（TCF）之间的相互作用参与驱动不同肿瘤（如结肠癌）的发生/发展，T细胞因子分解细胞增殖和分化中靶基因的表达。在癌细胞系中抑制该通路活性可有效阻断其生长。PNU-74654通过抑制β-catenin和TCF之间的相互作用抑制该通路。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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