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Merck
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文件

N9162

Sigma-Aldrich

Neocarzinostatin

from Streptomyces carzinostaticus, ≥90% (SDS-PAGE), solution

别名:

NCS, NSC-69856, 氟卡洛他汀, 齐诺他汀

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About This Item

CAS号:
9014-02-2
MDL號碼:
MFCD01778130
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

新卡他汀 来源于抑癌链霉菌, ≥90% (SDS-PAGE), ~0.5 mg/mL

品質等級

200

化驗

≥90% (SDS-PAGE)

形狀

solution

濃度

~0.5 mg/mL

抗生素活性譜

neoplastics

作用方式

DNA synthesis | interferes

運輸包裝

wet ice

儲存溫度

2-8°C

InChI

1S/C35H35NO12/c1-16-12-19(42-4)14-22-20(16)8-9-23(37)27(22)32(40)45-24-13-18-10-11-35(26-15-43-34(41)46-26)25(48-35)7-5-6-21(18)31(24)47-33-28(36-3)30(39)29(38)17(2)44-33/h8-9,12-14,17,21,24-26,28-31,33,36-39H,6,15H2,1-4H3/t17-,21?,24-,25-,26-,28-,29+,30-,31-,33-,35+/m1/s1

InChI 密鑰

BLXZMHNVKCEIJX-PNKAXBHOSA-N

應用

来自癌变链霉菌的新制癌菌素已被用于：
  • 作为治疗人成纤维细胞GM0637细胞的DNA损伤剂
  • 作为放射性模拟抗生素诱导DNA损伤
  • 与Vγ2Vδ2 T细胞结合以确定卵巢癌细胞中的细胞毒性

生化／生理作用

新制癌菌素是一种放射性模拟抗生素。
新制癌菌素是一种蛋白质-小分子复合物，由与113个氨基酸的单链蛋白紧密结合的烯二酮生色团组成。该复合物具有抗增殖和抗肿瘤活性。该生色团是负责DNA裂解的活性化合物；而载脂蛋白则稳定并调节不稳定生色团的利用率。NCS生色团通过非共价结合在结合蛋白的裂隙中，并且 是可分离的。在加入硫醇后，生色团会形成一种高度反应性的双自由基物种，可诱导DNA中序列特异性的单链和双链断裂。新制癌菌素能够抑制DNA合成，并在多种人类和动物肿瘤中具有抗肿瘤活性。NCS在人乳头瘤病毒（HPV）阳性和阴性细胞系中可通过诱导G2细胞周期阻滞和凋亡来抑制细胞增殖。

外觀

以含有20 mM MES缓冲液、pH 5.5的100 μg（~9 纳摩尔）的溶液提供

儲存類別代碼

10 - Combustible liquids

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Lu J,et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1842(7), 1071-1079 (2014)
B Heyd et al.
Journal of bacteriology, 182(7), 1812-1818 (2000-03-14)
Neocarzinostatin (NCS) is the most studied member of a family of chromoproteins secreted by a range of actinomycetes species. It has been proposed that in addition to their antitumoral activity related to the bound chromophores, this group of related proteins
Neocarzinostatin-chromophore: a potent inhibitor of casein kinase II in vitro.
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The enediyne antibiotics.
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