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Merck

N5501

Sigma-Aldrich

Nω-硝基-L-精氨酸

≥98% (TLC)

别名:

L-NNA, N5-(硝酰胺基)-L-2,5-二氨基戊酸, NG-NO2-L-精氨酸

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About This Item

经验公式(希尔记法):
C6H13N5O4
CAS号:
分子量:
219.20
Beilstein:
1728914
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic

品質等級

化驗

≥98% (TLC)

形狀

powder

mp

257 °C

溶解度

1 M HCl: 50 mg/mL, clear, colorless to faintly yellow

SMILES 字串

N[C@@H](CCCNC(=N)N[N+]([O-])=O)C(O)=O

InChI

1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m0/s1

InChI 密鑰

MRAUNPAHJZDYCK-BYPYZUCNSA-N

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應用

Nω-硝基-L-精氨酸已被用于:
  • 作为一氧化氮合成酶 (NOS) 抑制剂,用于测量细胞色素C还原检测中一氧化氮(NO)衍生物的释放量
  • 收缩研究用纤维束的预处理
  • 作为 NOS 抑制剂表征云南红豆杉 细胞中NO的生成
  • 作为神经元一氧化氮合成酶 (nNOS) 的不可逆抑制剂对浮囊制剂作进行预先温育处理

生化/生理作用

Nω-硝基-L-精氨酸/L-NNA 有助于降低高碳酸血症导致的皮质充血和大脑 cGMP的水平。
组成型一氧化氮合酶(nNOS)的不可逆抑制剂和诱导型一氧化氮合酶(iNOS)的可逆抑制剂。

特點和優勢

该化合物在受体分类和信号转导手册的一氧化氮合酶页面上有重点介绍。想要浏览手册的其他页面, 请单击此处

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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