N1019

(-)-尼古丁 半硫酸盐

≥95% (TLC), ~35 % (w/v) in H₂O (based on free base)

• 别名: (-)-1-甲基-2-(3-吡啶基)吡咯烷
• 线性分子式: (C₁₀H₁₄N₂)₂ · H₂SO₄
• CAS号: 65-30-5
• 分子量: 422.54
• MDL號碼: MFCD00148918
• 分類程式碼代碼: 12352210
• PubChem物質ID: 24897454
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (TLC)
• 形狀: liquid
• 濃度: ~35 % (w/v) in H₂O (based on free base)
• 顏色: dark brown
• SMILES 字串: OS(O)(=O)=O.CN1CCC[C@H]1c2cccnc2.CN3CCC[C@H]3c4cccnc4
• InChI: 1S/2C10H14N2.H2O4S/c2*1-12-7-3-5-10(12)9-4-2-6-11-8-9;1-5(2,3)4/h2*2,4,6,8,10H,3,5,7H2,1H3;(H2,1,2,3,4)/t2*10-;/m00./s1
• InChI 密鑰: IECQULMJVNSKDB-RCWTXCDDSA-N
• 基因資訊: human ... CHRNA4(1137) , CHRNB2(1141)

说明

一般說明

Nicotine is found in the leaves of Nicotiana species. It binds to nicotinic acetylcholine receptors and inhibits endogenous neurotransmitters. Nicotine is associated with lung cancer development and reduces the efficiency of chemotherapeutic agents. It is used to treat Alzheimer′s and Parkinson′s disease.

應用

(−)-Nicotine hemisulfate salt has been used to study the influence of nicotine on the severity of choroidal neovascularization (CNV). It also has been used as a natural nectar alkaloid to study the effect of self-medication in bumblebees.

生化／生理作用

原型烟酸乙酰胆碱受体激动剂;天然异构体。

品質

Mixture of nicotine base and nicotine sulfate.

注意

Shelf-life of the solution as supplied is at least six years when stored at room temperature.

安全信息

• 象形圖: GHS06,GHS09
• 訊號詞: Danger
• 危險聲明: H301,H310 + H330,H411
• 防範說明: P260 - P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• 危險分類: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3