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Merck

O100

Sigma-Aldrich

氧化震颤素M

solid

别名:

N,N,N,-三甲基-4-(2-氧代-1-吡咯烷基)-2-丁炔-1-碘化铵, 氧化震颤素甲碘化物

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About This Item

经验公式(希尔记法):
C11H19IN2O
CAS号:
分子量:
322.19
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

形狀

solid

顏色

white

溶解度

H2O: 24 mg/mL
ethanol: 4.6 mg/mL

儲存溫度

2-8°C

SMILES 字串

[I-].C[N+](C)(C)CC#CCN1CCCC1=O

InChI

1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14;/h6-10H2,1-3H3;1H/q+1;/p-1

InChI 密鑰

VVLMSCJCXMBGDI-UHFFFAOYSA-M

應用

氧化震颤素M已用作毒蕈碱型乙酰胆碱受体(mAchR)激动剂:
  • 用于研究其对秀丽隐杆线虫移动的急性效应
  • 用于处理海马体神经元,以便研究成纤维细胞生长因子受体1(FGFR1)的磷酸化作用
  • 用于诱发大鼠膀胱过度活动症

生化/生理作用

氧化震颤素M是一种非选择性毒蕈碱型乙酰胆碱受体激动剂。

特點和優勢

该化合物是《受体分类及信号转导手册》上乙酰胆碱受体(毒蕈硷)乙酰胆碱受体(烟碱)页面上的推荐化合物。想要浏览手册的其他页面, 请单击此处
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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M Gillard et al.
Molecular pharmacology, 32(1), 100-108 (1987-07-01)
We compared the binding characteristics of muscarinic receptors labeled by [3H]oxotremorine-M ([3H]oxo-M) in homogenates of brain cortex and heart from rat. In both tissues [3H]oxo-M bound, with the same KD (6.5 nM), to a fraction of the receptors labeled by
Yoshihiro Matsumoto et al.
Urology, 75(4), 862-867 (2010-02-17)
To investigate the effects of various muscarinic acetylcholine receptor (mAChR) antagonists, including selective M2 and M3 mAChR antagonists, on bladder overactivity. It has been proposed that the urothelium modulates the activity of bladder afferent pathways. However, the differential roles of
Pawan Bista et al.
Pflugers Archiv : European journal of physiology, 463(1), 89-102 (2011-11-16)
Modulation of the standing outward current (I (SO)) by muscarinic acetylcholine (ACh) receptor (MAChR) stimulation is fundamental for the state-dependent change in activity mode of thalamocortical relay (TC) neurons. Here, we probe the contribution of MAChR subtypes, G proteins, phospholipase
David R Thomas et al.
Neuropharmacology, 58(8), 1206-1214 (2010-03-09)
N-desmethylclozapine (NDMC) has been reported to display partial agonism at the human recombinant and rat native M(1) mAChR, a property suggested to contribute to the clinical efficacy of clozapine. However, the profile of action of NDMC at the human native
Detection of Fibroblast Growth Factor Receptor 1 (FGFR1) Transactivation by Muscarinic Acetylcholine Receptors (mAChRs) in Primary Neuronal Hippocampal Cultures Through Use of Biochemical and Morphological Approaches
"Reference Module in Food Science, 57-70 (2018)

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