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一般說明
SigmaMab抗体药物偶联物（ADC）模拟物是一种可用作质谱和高效液相色谱标准品的无毒性药物模拟物。ADC模拟物可通过LC-SMCC交联剂将SigmaMab（MSQC4）这种IgG1单克隆抗体与丹磺酰荧光团进行偶联。这种丹酰-LC-SMCC附着物可取代真实ADC的有毒载荷。
ADC模拟物可实现更安全、更一致的测试，使其成为优于真实ADC的最佳产品。与真实的ADC相比，它也是一种更具实惠的产品。借助这种无毒产品，LC-MS工艺可在更为安全的环境中被开发。
ADC模拟物可实现更安全、更一致的测试，使其成为优于真实ADC的最佳产品。与真实的ADC相比，它也是一种更具实惠的产品。借助这种无毒产品，LC-MS工艺可在更为安全的环境中被开发。
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
其他客户在看
Craig Jakes et al.
Analytical chemistry, 93(40), 13505-13512 (2021-09-30)
Monoclonal antibodies (mAbs) and related products undergo a wide range of modifications, many of which can often be directly associated to culture conditions during upstream processing. Ideally, such conditions should be monitored and fine-tuned based on real-time or close to
实验方案
SigmaMab Antibody Drug Conjugate Mimic, is a non-toxic drug mimic utilized as a standard for mass spectrometry and high performance liquid chromatography.
Here we show how LC and MS methods may be optimized using a non-toxic surrogate of the ADC, an “ADC-mimic”, that behaves very similarly to the Cys-linked ADC Adcetris (Seattle Genetics).
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