推荐产品
product name
Monoclonal Anti-Myelin Basic Protein (MBP) (36-50) antibody produced in rat, clone 14, tissue culture supernatant
生物源
rat
品質等級
共軛
unconjugated
抗體表格
tissue culture supernatant
抗體產品種類
primary antibodies
無性繁殖
14, monoclonal
包含
0.09% sodium azide
物種活性
horse, chicken, human
技術
ELISA: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
同型
IgG
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MBP(4155)
一般說明
Myelin basic protein (MBP) is part of the myelin sheath and is a calcium-dependent protein. It has six isoforms and the gene encoding it is localized on human chromosome 18q23.
特異性
Recognizes amino acids 36-50 of myelin basic protein.
免疫原
bovine myelin basic protein.
生化／生理作用
Myelin basic protein (MBP) associates with calmodulin and has been identified as an auto-antigen in multiple sclerosis (MS). It also inhibits the assembly of amyloid-β protein.
準備報告
Generated by somatic cell hybridization of NS0 myeloma cells with spleen cells from an outbred rat immunized with bovine myelin basic protein.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
其他客户在看
Alexey Belogurov et al.
The Journal of biological chemistry, 289(25), 17758-17766 (2014-04-18)
The vast majority of cellular proteins are degraded by the 26S proteasome after their ubiquitination. Here, we report that the major component of the myelin multilayered membrane sheath, myelin basic protein (MBP), is hydrolyzed by the 26S proteasome in a
Neha Soni et al.
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H K Palliser et al.
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Intra-uterine growth restriction (IUGR) is a significant in utero complication that can have profound effects on brain development including reduced myelination and deficits that can continue into adulthood. Progesterone increases oligodendrocyte proliferation and myelin expression, an action that may depend
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PloS one, 8(11), e79256-e79256 (2013-11-22)
Our knowledge about the neural code in the auditory nerve is based to a large extent on experiments on cats. Several anatomical differences between auditory neurons in human and cat are expected to lead to functional differences in speed and
Ekaterina Kuzina et al.
BioMed research international, 2014, 926394-926394 (2014-10-03)
We recently showed that myelin basic protein (MBP) is hydrolyzed by 26S proteasome without ubiquitination. The previously suggested concept of charge-mediated interaction between MBP and the proteasome led us to attempt to compensate or mimic its positive charge to inhibit
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