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product name
MPP 二盐酸盐 水合物, ≥97% (HPLC), white, powder
品質等級
化驗
≥97% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white
溶解度
DMSO: soluble ≥20 mg/mL
SMILES 字串
Cl.Cl.Cc1c(nn(-c2ccc(O)cc2)c1-c3ccc(OCCN4CCCCC4)cc3)-c5ccc(O)cc5
InChI
1S/C29H31N3O3.2ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;;/h5-16,33-34H,2-4,17-20H2,1H3;2*1H
InChI 密鑰
FWDNPWVVRVSJQH-UHFFFAOYSA-N
一般說明
甲基-哌啶基-吡唑水合物（MPP）可由甲基-吡唑-三醇（MPT）（一种吡唑三醇）进行制备。
應用
MPP二盐酸盐水合物已在下列研究中被用作雌激素受体α拮抗剂：
- 用于人乳腺癌MCF-7细胞中
- 预处理子宫内膜 离体 器官培养（EVOC）
- 处理垂体以监测促黄体激素的分泌
生化／生理作用
MPP 二盐酸盐是一种特异性雌激素受体 α拮抗剂。
甲基-哌啶基-吡唑水合物（MPP）是一种雌激素受体α激动剂，其缺乏雌激素受体（ER）的配体功能β。它可促进水飞蓟宾诱导的人乳腺癌MCF-7细胞凋亡。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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