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About This Item
经验公式（希尔记法）:
C31H38N2O7
CAS号:
分子量:
550.64
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.32
价格与库存信息目前不能提供
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化驗
≥97% (HPLC)
品質等級
形狀
powder
溶解度
methanol: 9.80-10.20 mg/mL, clear, yellow to very deep yellow
儲存溫度
2-8°C
SMILES 字串
CCCC[C@@H](C)\C=C(C)\C=C(/C)C(=O)NC1=C[C@@](O)(\C=C\C=C\C=C\C(=O)NC2=C(O)CCC2=O)[C@@H]3O[C@H]3C1=O
InChI
1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28?,29-,31+/m1/s1
InChI 密鑰
TWWQHCKLTXDWBD-YCWSEAROSA-N
應用
Manumycin A from Streptomyces parvulus has been used to inhibit IκB kinase (IKK)b−nuclear κ-B essential modulator (NEMO) interaction in the homogeneous time-resolved fluorescence (HTRF)-based binding assay.[1]
生化／生理作用
Manumycin A is a natural monomeric epoxyquinoid. It has an ability to inhibit tumor necrosis factor (TNF) induced IκB kinase (IKK) activity in various cell types. In addition, manumycin A exhibits anti-tumor property by inhibiting farnesylation of oncogenic Ras.[2]
Potent inhibitor of Ras farnesyltransferase.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Vivek Sharma et al.
Inflammation, 35(2), 516-519 (2011-05-11)
We have recently reported that Ras acts as an intermediate coactivator in IL-1β-mediated hypoxia-inducible factor-1α (HIF-1α) activation in glioblastoma multiforme (GBM). Since HIF-1α plays a crucial role in linking inflammatory and oncogenic pathways, we investigated whether this IL1β-Ras-HIF-1α signaling axis
Daniel Z Bar et al.
Nucleus (Austin, Tex.), 1(6), 499-505 (2011-02-18)
Fibroblasts derived from Hutchinson-Gilford progeria syndrome (HGPS) patients and dermal cells derived from healthy old humans in culture display age-dependent progressive changes in nuclear architecture due to accumulation of farnesylated lamin A. Treating human HGPS cells or mice expressing farnesylated
A homogeneous time-resolved fluorescence-based high-throughput screening system for discovery of inhibitors of IKK$\beta$--NEMO interaction
Gotoh Y, et al.
Analytical Biochemistry, 405(1), 19-27 (2010)
Pengfei Xie et al.
Applied microbiology and biotechnology, 96(2), 451-460 (2012-05-05)
Asukamycin, a member of the manumycin family of antibiotics, exhibits strong antibacterial, antifungal, and antineoplastic activities. However, its production in the wild-type strain of Streptomyces nodosus subsp. asukaensis ATCC 29757 is relatively low. Recently, the biosynthetic gene cluster for asukamycin
P K Singha et al.
Cell death & disease, 4, e457-e457 (2013-01-19)
Therapy resistance can be attributed to acquisition of anti-apoptotic mechanisms by the cancer cells. Therefore, developing approaches that trigger non-apoptotic cell death in cancer cells to compensate for apoptosis resistance will help to treat cancer effectively. Triple-negative breast cancers (TNBC)
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