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Merck
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文件

M4263

Sigma-Aldrich

丙二酰辅酶A 锂盐

≥90% (HPLC)

别名:

Malonyl CoA lithium salt

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About This Item

经验公式（希尔记法）:
C24H38N7O19P3S · xLi+
CAS号:
108347-84-8
分子量:
853.58 (free acid basis)
分類程式碼代碼:
41106305
PubChem物質ID:
24896812
NACRES:
NA.51

化驗

≥90% (HPLC)

溶解度

H2O: soluble 50 mg/mL protein, clear, colorless

儲存溫度

−20°C

SMILES 字串

[Li].CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O

InChI

1S/C24H38N7O19P3S.Li/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31;/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41);

InChI 密鑰

OPIJLICRFQMMJH-UHFFFAOYSA-N

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應用

丙二酰辅酶A锂盐已用于：
  • Krebs Ringer碳酸氢盐培养基，用于肪酸氧化测定之中的胰蛋白酶酶解和重悬成纤维细胞预培养
  • 脂肪酸合酶闪烁邻近测定的HEPES(4-(2-羟乙基)-1-哌嗪乙磺酸)缓冲液
  • 用作琥珀酰辅酶A连接酶测定中的反应混合物内标

生化／生理作用

丙二酰辅酶A是一种辅酶A衍生物，可用于脂肪酸和聚酮合成，以及胯线粒体膜α-转移酮戊二酸。丙二酰辅酶A是由乙酰辅酶A羧化酶介导的羧化反应生成。葡萄糖代谢也会产生丙二酰辅酶A。它会变构阻断肉碱棕榈酰转移酶1的作用，从而影响长链脂肪酸向线粒体的转移。脂肪酸合酶失活会导致丙二酰辅酶A过量，导致厌食。
辅酶A功能是作为酰基载体，乙酰-辅酶A。 丙二酰辅酶A是一种辅酶A衍生物，可用于脂肪酸和聚酮合成，以及胯线粒体膜转移酮戊二酸。丙二酰辅酶A是由乙酰辅酶A羧化酶介导的羧化反应生成。丙二酰辅酶A广泛用于细菌芳香族聚酮合成中的延伸单位。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Streptomyces glaucescens, a Gram-positive soil bacterium, produces the polyketide antibiotic tetracenomycin (Tcm) C. To study possible biochemical connections between the biosynthesis of bacterial fatty acids and polyketides, the abundant acyl carrier protein (ACP) detected throughout the growth of the tetracenomycin
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Recent studies have revealed that mitochondria are able to synthesize fatty acids in a malonyl-CoA/acyl carrier protein (ACP)-dependent manner. This pathway resembles bacterial fatty acid synthesis (FAS) type II, which uses discrete, nuclearly encoded proteins. Experimental evidence, obtained mainly through
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The FEBS journal, 278(4), 552-558 (2011-01-05)
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