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化驗
≥90%
儲存溫度
−20°C
SMILES 字串
[Li].CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(O)=O
InChI
1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/t14-,19-,20-,21?,25-/m1/s1
InChI 密鑰
SYKWLIJQEHRDNH-KRPIADGTSA-N
一般說明
戊二酰辅酶A（戊二酰CoA）是线粒体氧化赖氨酸、羟赖氨酸和色氨酸的中间体。
應用
戊二酰辅酶A锂盐已被用于：
- 通过定量蛋白质组学
- 对β-羟基β-甲基戊二酰-CoA（HMG-CoA）和戊二酰-CoA的酰基化进行比较性研究，作为FapR-NLuc蛋白
- 体外生物传感器活性实验的测定缓冲液的组成部分，以测试其对a549裂解物中丙酮酸激酶活性抑制的效应
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Genetically Encoded FapR-NLuc as a Biosensor to Determine Malonyl-CoA in Situ at Subcellular Scales.
Yipeng Du et al.
Bioconjugate chemistry, 30(3), 826-832 (2019-01-11)
Malonyl-CoA is one of the key metabolic intermediates in fatty acid metabolism as well as a key player in protein post-translational modifications. Detection of malonyl-CoA in live cells is challenging because of the lack of effective measuring tools. Here we
Kinetic mechanism of glutaryl-CoA dehydrogenase
Rao K S, et al.
Biochemistry, 45(51), 15853-15861 (2006)
Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases.
Simon Wischgoll et al.
Biochemistry, 49(25), 5350-5357 (2010-05-22)
Glutaryl-coenzyme A dehydrogenases (GDHs) involved in amino acid degradation were thought to catalyze both the dehydrogenation and decarboxylation of glutaryl-coenzyme A to crotonyl-coenzyme A and CO(2). Recently, a structurally related but nondecarboxylating, glutaconyl-coenzyme A-forming GDH was characterized in the obligately
Rhushikesh A Kulkarni et al.
Cell chemical biology, 24(2), 231-242 (2017-02-07)
Non-enzymatic protein modification driven by thioester reactivity is thought to play a major role in the establishment of cellular lysine acylation. However, the specific protein targets of this process are largely unknown. Here we report an experimental strategy to investigate
Discovering targets of non-enzymatic acylation by thioester reactivity profiling
Kulkarni RA, et al.
Cell Chemical Biology, 24(2), 231-242 (2017)
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