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生物源
guinea pig brain
品質等級
化驗
≥80% (SDS-PAGE)
形狀
lyophilized powder
技術
cell based assay: suitable
UniProt登錄號
應用
cell analysis
儲存溫度
−20°C
基因資訊
guinea pig ... MBP(100731253)
一般說明
在豚鼠脑中表达的髓鞘碱性蛋白（MBP）含有 167 个氨基酸，分子量为 18,256Da。
髓鞘碱性蛋白(MBP)是CNS（中枢神经系统）髓鞘的重要组成部分。它是一种自身免疫原。MBP定位于人染色体18q上。
應用
Myelin Basic Protein fromguinea pig brain has been used as a kinase substrate: to analyse in vitrokinase activity, in protein phosphorylation analysis, in ATG1 kinaseassay
生化／生理作用
髓磷脂碱性蛋白（MBP）在髓鞘的形成中起重要作用，并且与各种神经障碍有关。髓磷脂碱性蛋白作为自身免疫疾病实验性变应性脑脊髓炎（EAE）中的抗原靶标起作用。髓磷脂碱性蛋白在细胞骨架更新和膜延伸中起重要作用。此外，它还参与 Fyn 介导的信号途径、磷酸肌醇的隔离和钙稳态的调节。髓磷脂碱性蛋白作为丝裂原活化蛋白激酶（MAP）激酶的体外底物起作用，并有助于酶的纯化和功能研究。
髓鞘碱性蛋白基因的突变诱导髓鞘形成；用于诱导实验性过敏性脑脊髓炎。
品質
可能含有微量尿素-甘氨酸缓冲液盐。
原則
用作激酶底物。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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