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M1195

Metolazone

Name: Metolazone
Brand: SIGMA

≥98% (HPLC), solid

别名:

7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

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About This Item

经验公式（希尔记法）:

C₁₆H₁₆ClN₃O₃S

CAS号:

17560-51-9

分子量:

365.83

EC號碼:

241-539-3

MDL號碼:

MFCD00069304

分類程式碼代碼:

12352200

PubChem物質ID:

24724532

NACRES:

NA.77

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Sigma-Aldrich

T1633

茶碱

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

顏色

white

溶解度

DMSO: >5 mg/mL

SMILES 字串

CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O

InChI

1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)

InChI 密鑰

AQCHWTWZEMGIFD-UHFFFAOYSA-N

基因資訊

human ... SLC12A1(6557) , SLC12A3(6559)

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生化／生理作用

Inhibitor of thiazide-sensitive Na⁺-Cl^- cotransporter; antihypertensive; moderate "loop" diuretic.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析证书(COA)

Lot/Batch Number

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Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction.

A Monroy et al.

American journal of physiology. Renal physiology, 279(1), F161-F169 (2000-07-15)

The thiazide-sensitive Na(+)-Cl(-) cotransporter (TSC) is the major pathway for salt reabsorption in the apical membrane of the mammalian distal convoluted tubule. When expressed in Xenopus laevis oocytes, rat TSC exhibits high affinity for both cotransported ions, with the Michaelis-Menten

Age- and gender-related use of low-dose drug therapy: the need to manufacture low-dose therapy and evaluate the minimum effective dose.

P A Rochon et al.

Journal of the American Geriatrics Society, 47(8), 954-959 (1999-08-12)

Low-dose drug therapy is promoted as a way to maximize benefit and minimize adverse drug effects when prescribing for older adults. This population-based study evaluates the age and sex-related use of two common therapies: thiazide diuretics, where evidence supports the

Hydroxychloroquine-induced hyperpigmentation: the staining pattern.

Puja K Puri et al.

Journal of cutaneous pathology, 35(12), 1134-1137 (2008-08-30)

We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female (case 1) and a 78-year-old female (case 2), both receiving 400 mg per day. Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated

Difficulties of introducing the National Service Framework for heart failure into general practice in the UK.

Nigel Sparrow et al.

European journal of heart failure, 5(3), 355-361 (2003-06-12)

The National Service Framework (NSF) sets standards for the management of heart failure in the UK. Loop diuretics are commonly first prescribed in primary care. Some patients taking these drugs have heart failure and may benefit from other treatments including

Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature.

Jens Rosenberg et al.

Cardiovascular drugs and therapy, 19(4), 301-306 (2005-09-29)

Metolazone is a potent thiazide-like diuretic. It is recommended in severe congestive heart failure (HF). We conducted a review of the existing literature and found that the available information on the use of metolazone in HF is based on studies

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