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Merck
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主要文件

L9507

Sigma-Aldrich

乳铁蛋白 来源于牛奶

≥85% (SDS-PAGE)

别名:

Bos d LF, Lactotransferrin

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About This Item

CAS号:
936541-36-5
MDL编号:
MFCD00131481
UNSPSC代码:
12352202
NACRES:
NA.61
价格与库存信息目前不能提供

生物来源

bovine milk

质量水平

200

方案

≥85% (SDS-PAGE)

表单

powder

分子量

~87 kDa

技术

fractionation: suitable

溶解性

H2O: soluble 10 mg/mL

UniProt登记号

P24627

储存温度

2-8°C

基因信息

cow ... LTF(280846)

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应用

乳铁蛋白被用于通过阳离子交换膜从牛体内分离乳过氧化物酶和乳铁蛋白。[1]它被用于通过新型免疫传感器测定动物乳汁中的乳铁蛋白和免疫球蛋白G。[2]

生化/生理作用

乳铁蛋白是一种铁结合蛋白。 它的结构与转铁蛋白类似，即血浆铁转运蛋白；但乳铁蛋白对铁的亲和力要高得多（250倍）。它在初乳中的含量非常高，并且在泪液、唾液、粘液分泌物和中性粒细胞的次级颗粒中也少量存在。它由粘膜上皮和嗜中性粒细胞产生，由这些细胞在炎症刺激下释放。乳铁蛋白可以通过与铁螯合而抑制细菌生长，并且通过其N-末端与脂多糖结合而增加细菌细胞壁通透性。乳铁蛋白可以通过与病毒包膜蛋白紧密结合而抑制病毒感染。这能够阻断细胞与病毒的结合域，从而防止细胞-病毒融合。乳铁蛋白可能通过刺激白细胞介素-8（一种中性粒细胞激活剂）的释放而激活宿主防御系统。 它还可能参与抗体和白细胞介素合成、淋巴细胞增殖和补体激活。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000382758
0000328874
0000328875
0000320656
0000320658

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Víctor A Solarte et al.
BioMed research international, 2015, 630179-630179 (2015-11-27)
Several short linear peptides derived from cyclic bovine lactoferricin were synthesized and tested for their cytotoxic effect against the oral cavity squamous-cell carcinoma (OSCC) cell lines CAL27 and SCC15. As a control, an immortalized and nontumorigenic cell line, Het-1A, was
Qianqian Yao et al.
PeerJ, 9, e11072-e11072 (2021-06-17)
Colorectal cancer is a common cause of death with few available therapeutic strategies, and the preventative complexes in adjunctive therapy are urgently needed. Increasing evidences have shown that natural ingredients, including lactoferrin, oleic acid, docosahexaenoic acid (DHA) and linolenic acid
Mona M Abdel-Wahab et al.
Fish & shellfish immunology, 111, 160-169 (2021-02-09)
The present study was carried out to investigate the effects of dietary bovine lactoferrin (BLF) or chitosan nanoparticles (CHN) alone or in combinations on serum biochemical indices, antioxidative capacity, transcriptomic responses, non-specific immunity, and resistance of Nile tilapia (Oreochromis niloticus)
Chih-Ching Yen et al.
Molecular imaging and biology, 22(3), 526-538 (2019-07-10)
High levels of oxygen are usually used in ventilatory support and extracorporeal membrane oxygenation (ECMO) in the intensive care unit of hospitals. Hyperoxia may induce the production of reactive oxygen species (ROS) that can cause lung damage and even systemic
Ji Yong Yin et al.
Biomedical and environmental sciences : BES, 30(12), 875-886 (2018-01-18)
To research a protein chip method which can simultaneously quantitative detect β-Lactoglobulin (β-L) and Lactoferrin (Lf) at one time. Protein chip printer was used to print both anti-β-L antibodies and anti-Lf antibodies on each block of protein chip. And then
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Questions

  1. Is this product dissolvable in plant based oils?

    1 answer

    1. This product has not been tested for solubility in plant oils. However, it can be solubilized in water and aqueous solutions, 10 mg/mL of water and 1 mg/mL of PBS, respectively. A brief search of the literature shows that oil emulsions have been frequently studied.

      See the link below for a publication that may be helpful.
      https://pubs.acs.org/doi/full/10.1021/jf9809939

      Helpful?

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