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Merck

L5288

Sigma-Aldrich

Latrunculin B

from Latruncula magnifica, ≥80% (HPLC), solid, actin polymerization inhibitor

别名:

LAT-B

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About This Item

经验公式(希尔记法):
C20H29NSO5
CAS号:
分子量:
395.51
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

产品名称

拉春库林 B 来源于Latruncula magnifica, ≥80% (HPLC), solid

质量水平

方案

≥80% (HPLC)

表单

solid

分子量

395.5

溶解性

ethanol: soluble

储存温度

−20°C

SMILES字符串

C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CCC=C1

InChI

1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1

InChI key

NSHPHXHGRHSMIK-JRIKCGFMSA-N

一般描述

拉春库林 B是一种大环毒素,由红海海绵(Latruncula magnifica )产生。

应用

来自红海海绵(Latruncula magnifica )的拉春库林 B在各种实验中用于肌动蛋白解聚。它还被用作骨髓来源树突状细胞 (BMDC)完全培养基中的一种成分,用于研究树突状细胞中吞噬体小管的形成。

生化/生理作用

拉春库林B 在体外抑制肌动蛋白聚合。拉春库林B破坏了微丝介导的过程。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Microtubule-dependent targeting of the exocyst complex is necessary for xylem development in Arabidopsis
Vukavsinovic N, et al.
The New phytologist, 213(3), 1052-1067 (2017)
Li-Kun Phng et al.
Development (Cambridge, England), 140(19), 4031-4040 (2013-09-21)
Actin filaments are instrumental in driving processes such as migration, cytokinesis and endocytosis and provide cells with mechanical support. During angiogenesis, actin-rich filopodia protrusions have been proposed to drive endothelial tip cell functions by translating guidance cues into directional migration
Visualizing toll-like receptor-dependent phagosomal dynamics in murine dendritic cells using live cell microscopy
Mantegazza AR and Marks MS
Methods in Molecular Biology, 191-203 (2015)
Development of the theta comparative cell scoring method to quantify diverse phenotypic responses between distinct cell types
Warchal SJ, et al.
Assay and Drug Development Technologies, 14(7), 395-406 (2016)
C A de Oliveira et al.
Life sciences, 43(22), 1825-1830 (1988-01-01)
We have found that latrunculin A, a Red Sea sponge toxin, is a potent inhibitor of immunological phagocytosis by mouse peritoneal macrophages, but does not block the binding (recognition) of the immune complexes (erythrocytes sensitized with IgG antibodies) to the

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