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Merck
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Key Documents

L2777

Sigma-Aldrich

Lisinopril

ACE Inhibitor

别名:

(S)-Nα-(1-Carboxy-3-phenylpropyl)-Lys-Pro

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About This Item

EC號碼:
278-488-1
分類程式碼代碼:
12352204
NACRES:
NA.26

一般說明

Lisinopril is a nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. It is used in the treatment of heart failure and hypertension. Lisinopril is an antihypertensive and anticongestive agent, like other members of its family. It is water-soluble and possesses weak chelating properties.

應用

Lisinopril has been used as an angiotensin-converting enzyme (ACE) inhibitor:
  • in combination with spironolactone, to study their effects on cardiac and skeletal muscles in the Duchenne muscular dystrophy (DMD) mice model
  • standard in in vitro ACE inhibitory assay
  • as a negative control in ACE enzymatic assay

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H360D,H373

危險分類

Repr. 1A - STOT RE 2

標靶器官

Kidney

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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美托洛尔 (+)-酒石酸盐 ≥98% (titration), powder

Sigma-Aldrich

M5391

美托洛尔 (+)-酒石酸盐

氯沙坦钾

Supelco

61188

氯沙坦钾

ACE Inhibitory Peptides from Bellamya bengalensis Protein Hydrolysates: In Vitro and In Silico Molecular Assessment
Dey T K, et al.
Processes, 9(8), 1316-1316 (2021)
Prednisolone Attenuates Improvement of Cardiac and Skeletal Contractile Function and Histopathology by Lisinopril and Spironolactone in the mdx Mouse Model of Duchenne Muscular Dystrophy
Paul M.L
PLoS ONE (2014)
V B Sørensen et al.
Clinical science (London, England : 1979), 95(6), 709-717 (1998-12-01)
1. Our objective was to compare the effect of a long-acting calcium antagonist (nisoldipine) compared with an angiotensin-converting enzyme inhibitor (lisinopril) on the non-neurogenic regulation of the microvascular blood flow in hypertensive Type I diabetes patients with diabetic nephropathy.2. We
Angiotensin converting enzyme inhibitors: comparative structure, pharmacokinetics, and pharmacodynamics.
Thind GS
Cardiovascular Drug Reviews (1990)
R L Hamlin et al.
Journal of veterinary internal medicine, 12(2), 93-95 (1998-04-30)
This study was designed to determine the degree of inhibition of the angiotensin-converting enzyme (ACE) in 5 normal dogs given single doses of conventionally used ACE inhibitors (ACEis). In addition the time required for that inhibition to return to 50%
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