所有图片(1)
About This Item
经验公式（希尔记法）:
C14H16N3OCl
CAS号:
分子量:
277.75
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
white to off-white
溶解度
DMSO: >20 mg/mL
H2O: insoluble
起源
Johnson & Johnson
儲存溫度
room temp
SMILES 字串
CN1CCN(CC1)C(=O)c2cc3cc(Cl)ccc3[nH]2
InChI
1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
InChI 密鑰
HUQJRYMLJBBEDO-UHFFFAOYSA-N
應用
JNJ7777120 has been used as a histamine-4 receptor antagonist:
- to study its effects on the pro-inflammatory microglia in rats
- to study its effects on the Parkinson′s-like pathology in rat brain
- to study its effects on the histamine receptor interaction in periodontal ligament fibroblasts (PDLF)
生化／生理作用
JNJ7777120 may exhibit neuroprotective effects against ischemic brain damage. It acts as an anti-inflammatory agent to treat inflammatory diseases. JNJ7777120 is observed to reduce colonic injury, cytokine production, and neutrophil infiltration.
JNJ7777120 is a potent, selective non-imidazole H4 histamine receptor antagonist.
特點和優勢
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Susanne Mommert et al.
International archives of allergy and immunology, 166(3), 225-230 (2015-05-01)
Natural killer (NK) cells have been detected in the lesional skin of patients with inflammatory skin diseases, where high levels of histamine are also present. Therefore, we investigated the effect of histamine, in particular via the histamine H4 receptor (H4R)
Qiuyuan Fang et al.
Brain, behavior, and immunity, 92, 127-138 (2020-11-30)
Growing evidence indicates that microglia activation and a neuroinflammatory trigger contribute to dopaminergic cell loss in Parkinson's disease (PD). Furthermore, increased density of histaminergic fibers and enhanced histamine levels have been observed in the substantia nigra of PD-postmortem brains. Histamine-induced
E Zampeli et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 58(6), 285-291 (2009-02-03)
Although the H(4) receptor localisation in the eye is unresolved, this study aimed to investigate the effects of the H(4) receptor antagonist JNJ7777120 in a model of experimental conjunctivitis. JNJ7777120, at 0.005-1 mmol/l, was instilled into the lower conjunctival fornix
Heiko Schenk et al.
Immunopharmacology and immunotoxicology, 38(5), 379-384 (2016-08-26)
The modulation of antigen uptake and activation of dendritic cells (DCs) by histamine may function as a regulator of inflammation. Therefore, we sought to determine the impact of histamine on antigen uptake by and activation of murine DCs. DCs from
Ilaria Dettori et al.
Frontiers in pharmacology, 9, 1231-1231 (2018-11-14)
Cerebral ischemia is a multifactorial pathology characterized by different events evolving in time. The acute injury, characterized by excitoxicity, is followed by a secondary brain injury that develops from hours to days after ischemia. Extracellular levels of histamine increase in
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