推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
技術
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500
免疫原序列
TNEIANANSRQQIRKLIKDGLIIRKPVTVHSRARCRK
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... RPL19(6143)
一般說明
Ribosomal protein L19 (RPL19) is a member of L19E super-family of proteins and is a component of the ribosomal large 60S subunit. The gene is located on human chromosome 17q12. Ribosomal protein L19 (RPL19) consists of a promoter between -210 and -250, which is required for gene activity.
免疫原
ribosomal protein L19 recombinant protein epitope signature tag (PrEST)
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-RPL19 antibody produced in rabbit has been used in immunofluorescence.
生化／生理作用
The protein has an extra-protein translational function. Upregulation of RPL19 stimulates michigan cancer foundation-7 (MCF7) breast cancer cells to endoplasmic reticulum (ER) stress-induced cell death. It functions as a tumor antigen in lung adenocarcinoma. The protein is a poor prognostic marker for colorectal cancer. It is an important modulator of cellular phenotype. The protein is used as a prognostic marker for prostate cancer.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST82665
外觀
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
The L19 ribosomal protein gene (RPL19): Gene organization, chromosomal mapping, and novel promoter region
Davies B and Fried M
Genomics, 25(2), 372-380 (1995)
17q12-21-The pursuit of targeted therapy in breast cancer
Glynn RW, et al.
Cancer Treatment Reviews, 36(3), 224-229 (2010)
Ribosomal protein l19 is a prognostic marker for human prostate cancer
Bee A, et al.
Clinical Cancer Research, 12(7), 2061-2065 (2006)
siRNA knockdown of ribosomal protein gene RPL19 abrogates the aggressive phenotype of human prostate cancer
Bee A, et al.
PLoS ONE, 6(7), e22672-e22672 (2011)
DNA Ends Alter the Molecular Composition and Localization of Ku Multi-component Complexes
Adelmant G, et al.
Molecular and Cellular Proteomics, mcp-M111 (2012)
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