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Merck
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主要文件

HPA005459

Sigma-Aldrich

Anti-α-Synuclein (SNCA) Antibody

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, rabbit polyclonal

别名:

Anti-NACP, Anti-PARK1, Anti-PARK4, Anti-alpha-synuclein, Anti-synuclein, alpha (non A4 component of amyloid precursor)

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About This Item

UNSPSC代码:
12352203
人类蛋白质图谱编号:
NACRES:
NA.41

产品名称

抗 SNCA 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

产品线

Prestige Antibodies® Powered by Atlas Antibodies

表单

buffered aqueous glycerol solution

种属反应性

human

增强验证

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

技术

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:20-1:50

免疫原序列

EGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPE

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... SNCA(6622)

一般描述

Synuclein alpha (SNCA) is expressed in the central nervous system, which includes astrocytes, neurons, oligodendroglia and microglia. The gene is located on human chromosome 4q22.1. It is a small protein containing 140 amino acids.

免疫原

synuclein, alpha (non A4 component of amyloid precursor) recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

生化/生理作用

Synuclein alpha (SNCA) aids brain fatty acid metabolism, dopamine biosynthesis, dopamine transporter modulation, chaperone activity and regulation of inflammatory response. The protein inhibits phospholipase D2. It is considered as a biomarker for group 4 medulloblastomas. It has the capacity to inhibit tumor invasion and induce apoptosis. Aggregation of SNCA in central nervous system is associated with Lewy body dementia (LBD) and Parkinson′s disease(PD). The protein may be involved in neurotransmitter release and vesicle turnover at the presynaptic terminals.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST86754

外形

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律信息

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

The central theme of Parkinson?s disease: α-synuclein
Ozansoy M and Bacsak AN
Molecular Neurobiology, 47(2), 460-465 (2013)
Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease
Blauwendraat C, et al
Neurobiology of Aging, 64(2), 159-e5-159-e5 (2018)
Altered expression of the synuclein family mRNA in Lewy body and Alzheimer?s disease
Rockenstein E, et al.
Brain Research, 914(1-2), 48-56 (2001)
Lipopolysaccharide-induced blood brain barrier permeability is enhanced by alpha-synuclein expression
Jangula A and Murphy EJ
Neuroscience Letters, 551(7), 23-27 (2013)
SNCA, a novel biomarker for Group 4 medulloblastomas, can inhibit tumor invasion and induce apoptosis
Li YX, et al.
Cancer Science, 109(4), 1263-1275 (2018)

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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