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Merck

H3911

SAFC

L-组氨酸

制药生产

别名:

(S)-2-氨基-3-(4-咪唑基)丙酸, NSC 137773

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About This Item

经验公式(希尔记法):
C6H9N3O2
CAS号:
分子量:
155.15
Beilstein:
84088
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
NACRES:
NA.26

生物源

non-animal source

品質等級

化驗

≥98.5%

形狀

crystalline powder

技術

cell culture | mammalian: suitable

雜質

endotoxin, heavy metals, trace metals, residual solvents, tested

mp

282 °C (dec.) (lit.)

溶解度

H2O: 50 mg/mL

適合性

suitable for manufacturing use

應用

pharmaceutical (small molecule)

異物活動

cytotoxicity, tested

SMILES 字串

N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChI 密鑰

HNDVDQJCIGZPNO-YFKPBYRVSA-N

基因資訊

human ... CA1(759) , CA2(760)

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我们用于生物制药加工的SAFC® 系列优质原料经过严格的质量控制流程,配合记录文件和技术专长帮助我们的客户达到M-Clarity Program规定的要求。

M-Clarity Program

我们全面的上游工艺化学品系列不仅为生物制药生产商提供生产传统和创新治疗药物所需的优质原料,而且帮助他们更快地将产品投放市场并简化监管问题。请相信我们能够为您带来透明的供应链和可靠的全球采购能力,以最佳的法规支持和服务简化您的产品认证。

應用

L-组氨酸是一种必需氨基酸。它用作细胞培养基组分,用于治疗性重组蛋白和单克隆抗体的商业生物制造。

生化/生理作用

组胺的前体,经组氨酸脱羧酶作用可生成组胺。

法律資訊

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Pawel Swietach et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), E2064-E2073 (2013-05-17)
Ca(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to
H M Golder et al.
Journal of dairy science, 97(8), 5131-5150 (2014-06-03)
Ruminal bacterial community composition (BCC) and its associations with ruminal fermentation measures were studied in dairy heifers challenged with combinations of grain, fructose, and histidine in a partial factorial study. Holstein-Friesian heifers (n=30) were randomly allocated to 5 triticale grain-based
Shweta Singh et al.
Microbial cell factories, 7, 28-28 (2008-10-14)
The large-scale production of G-protein coupled receptors (GPCRs) for functional and structural studies remains a challenge. Recent successes have been made in the expression of a range of GPCRs using Pichia pastoris as an expression host. P. pastoris has a
Urszula Kosinska Eriksson et al.
Science (New York, N.Y.), 340(6138), 1346-1349 (2013-06-15)
Aquaporins are membrane channels that facilitate the flow of water across biological membranes. Two conserved regions are central for selective function: the dual asparagine-proline-alanine (NPA) aquaporin signature motif and the aromatic and arginine selectivity filter (SF). Here, we present the
Smriti Kala et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(16), 6022-6027 (2014-04-09)
The genome packaging reactions of tailed bacteriophages and herpes viruses require the activity of a terminase enzyme, which is comprised of large and small subunits. Phage genomes are replicated as linear concatemers composed of multiple copies of the genome joined

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