推荐产品
生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
≥80% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
分子量
185 kDa
包裝
pkg of 100 μg
儲存條件
avoid repeated freeze/thaw cycles
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... NRG1(3084)
相关类别
一般說明
Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.
生化／生理作用
Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.
外觀
Solution in phosphate buffered saline containing 30% glycerol.
分析報告
Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.
The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Marcia R Campbell et al.
Cell reports, 38(5), 110291-110291 (2022-02-03)
Effective inactivation of the HER2-HER3 tumor driver has remained elusive because of the challenging attributes of the pseudokinase HER3. We report a structure-function study of constitutive HER2-HER3 signaling to identify opportunities for targeting. The allosteric activation of the HER2 kinase
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