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product name
肝素结合EGF 样生长因子 人, HB-EGF, recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
生物源
human
品質等級
重組細胞
expressed in baculovirus infected Sf21 cells
化驗
≥97% (SDS-PAGE and N-terminal analysis)
形狀
lyophilized powder
效力
≤3 ng/mL
品質
endotoxin tested
分子量
9.5 kDa
包裝
pkg of 50 and 250 μg
儲存條件
avoid repeated freeze/thaw cycles
技術
cell culture | mammalian: suitable
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... HBEGF(1839) , HBEGF(1839)
生化／生理作用
与BTC一样，肝素结合表皮生长因子（HB-EGF）是肝素结合EGF家族的成员。天然可溶性HB-EGF是一种19 kDa的糖蛋白，因异质性截短而具有多种形式。可溶性HB-EGF对成纤维细胞、角质形成细胞和平滑肌细胞具有促有丝分裂和趋化作用，但对毛细血管内皮细胞则没有。在单核细胞、巨噬细胞以及血管和主动脉平滑肌细胞（SMC）中可检测到HB-EGF的产生。HB-EGF在动脉粥样硬化的发病机理中可能会起作用。它也可能是Jun诱导的致癌转化的效应因子。HB-EGF可以高亲和力与EGFR结合，并以中等亲和力与ErbB结合。
外觀
从含有2.5 mg牛血清白蛋白并经0.2 μm滤膜过滤的磷酸盐缓冲盐中冻干。
分析報告
生物活性通过它在EGF反应性BALB/3T3细胞中刺激3H-胸苷掺入的能力来测量。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
U Palmer et al.
The European respiratory journal, 14(2), 405-411 (1999-10-09)
Signalling through epidermal growth factor (EGF) receptor leads to several cellular responses including cell division and cell migration. Since EGF receptors are expressed on normal mesothelial cells, this study investigated whether EGF receptor ligands act as chemoattractants on these cells.
F Vinante et al.
Blood, 94(9), 3169-3177 (1999-11-11)
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a widely expressed EGF superfamily member that induces mitogenic and/or chemotactic activities toward different cell types through binding to EGF receptors 1 or 4. Membrane-bound HB-EGF exerts growth activity and adhesion capabilities
M Lanzrein et al.
The Biochemical journal, 310 ( Pt 1), 285-289 (1995-08-15)
Preincubation of Vero cells with 1 microM phorbol 12-myristate 13-acetate (PMA) decreased the specific binding of diphtheria toxin by about 50%, whereas the toxic effect, endocytic uptake and membrane translocation were completely blocked. Toxin bound to PMA-treated cells was released
R Iwamoto et al.
The Journal of biological chemistry, 274(36), 25906-25912 (1999-08-28)
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) transduces mitogenic signals through the EGF receptor (EGFR). There are two forms of HB-EGF, the membrane-anchored form (pro-HB-EGF) and the soluble form (sHB-EGF). We studied the biological activity of pro-HB-EGF by using a
Zizheng Li et al.
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