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Merck

F8182

Sigma-Aldrich

法罗培南钠 水合物

≥98% (HPLC)

别名:

(5R,6S,8R,2′R)-2-(2′-四氢呋喃基)-6-羟乙基青霉烯-3-羧酸钠盐, ALP 201, SUN 5555, SY 5555, Wy 49605, 呋罗培南, 法罗培南, 法罗培南钠片

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About This Item

经验公式(希尔记法):
C12H14NNaO5S · xH2O
分子量:
307.30 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
价格与库存信息目前不能提供

质量水平

方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D +120 to +130°, c = 1.0 in water

储存条件

desiccated

颜色

white to light brown

溶解性

H2O: ≥20 mg/mL

创始人

Daiichi-Sankyo

储存温度

−20°C

SMILES字符串

O.[Na+].C[C@@H](O)C1C2SC(C3CCCO3)=C(N2C1=O)C([O-])=O

InChI

1S/C12H15NO5S.Na.H2O/c1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6;;/h5-7,11,14H,2-4H2,1H3,(H,16,17);;1H2/q;+1;/p-1/t5-,6-,7+,11-;;/m1../s1

InChI key

FHSVCMPZCIOKGW-VIDQLUEFSA-M

相关类别

一般描述

法罗培南钠水合物属于口服处方的青霉类抗生素。[1]具有头孢菌素抗性的肠杆菌科细菌感染易受法罗培南的影响。[2][3]法罗培南可能是治疗由广谱β-内酰胺酶(ESBL)产生细菌引起的尿路感染的一种有效的抗生素。[2]

生化/生理作用

属于培南类的光谱β-内酰胺抗生素;β-内酰胺酶稳定。
法罗培南钠是一种超广谱、耐受β-内酰胺酶的β-内酰胺抗生素,对革兰氏阳性和革兰氏阴性细菌均具有活性。

特点和优势

该化合物由Daiichi-Sankyo开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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J M Woodcock et al.
The Journal of antimicrobial chemotherapy, 39(1), 35-43 (1997-01-01)
The in-vitro activity of faropenem, a novel oral penem, was studied in comparison with other beta-lactam antimicrobials against 711 recent clinical isolates including Gram-negative, Gram-positive and anaerobic bacteria. MIC data showed that faropenem was active against most members of the
E Inoue et al.
Antimicrobial agents and chemotherapy, 38(9), 1974-1979 (1994-09-01)
The antibacterial activity of SY5555, a new oral penem antibiotic, was compared with those of cefaclor, cefixime, and cefteram. SY5555 was more active than the comparison agents against methicillin-susceptible Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Enterococcus faecalis, Citrobacter freundii, Enterobacter
Novel carbon-carbon bond cleavage reaction of penem antibiotic by class C beta-lactamases.
R Tanaka et al.
The Journal of antibiotics, 47(8), 945-948 (1994-08-01)
T Sekiguchi et al.
The Japanese journal of antibiotics, 48(2), 220-228 (1995-02-01)
SY5555 in dry syrup (powder which is dissolved before use) or tablet form was given orally to 21 children with acute bacterial infections including 4 with acute pharyngitis, 5 with acute tonsillitis, 7 with acute bronchitis, 2 with acute gastroenteritis
D Sewell et al.
Antimicrobial agents and chemotherapy, 39(7), 1591-1595 (1995-07-01)
The in vitro activity of WY-49605 (SUN5555) (WY) was compared with those of cefaclor, cefixime, and amoxicillin-clavulanic acid against 2,958 consecutive clinical isolates from five medical centers and 402 respiratory pathogens from 18 other facilities. Most members of the family

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