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Merck

E7138

Sigma-Aldrich

乙琥胺

别名:

2-乙基-2-甲基琥珀酰亚胺

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About This Item

经验公式(希尔记法):
C7H11NO2
CAS号:
分子量:
141.17
EC 号:
MDL编号:
UNSPSC代码:
12352111
PubChem化学物质编号:
NACRES:
NA.77
价格与库存信息目前不能提供

质量水平

溶解性

ethanol: 100 mg/mL

SMILES字符串

O=C1NC(CC1(C)CC)=O

InChI

1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

InChI key

HAPOVYFOVVWLRS-UHFFFAOYSA-N

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应用

乙琥胺已被用于:
  • 证实其对大鼠棘波放电(SWD)的作用[1]
  • 考察其对野生型斑马鱼幼体自发运动和焦虑相关趋触性行为的影响[2]
  • 作为模型药物体内治疗癫痫症(4)

生化/生理作用

乙琥胺是一种抗惊厥药[3],同时也是T型钙通道拮抗剂。它可防止失神发作中的棘波放电。[1]

特点和优势

该化合物在受体分类和信号转导手册的钙通道页面上有重点介绍。如需浏览其他手册页面,请点击此处

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Self-assembling PVA-F127 thermosensitive nanocarriers with highly sensitive magnetically-triggered drug release for epilepsy therapy in vivo
Huang HY, et al.
Journal of Materials Chemistry, 22(17), 8566-8573 (2012)
Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy
Pearce PS, et al.
Epilepsy & Behavior : E&B, 32, 121-131 (2014)
Behavioural responses of zebrafish larvae to acute ethosuximide exposure
Ji Y, et al.
Behavioural Pharmacology, 28(6), 428-440 (2017)
Shang-Der Chen et al.
Epilepsia, 52(7), 1311-1318 (2011-07-07)
Generalized absence seizures are characterized by bilateral spike-wave discharges (SWDs), particularly in the frontoparietal cortical region. In WAG/Rij and GAERS rats with absence epilepsy, recent evidence indicates that SWDs arise first from the lateral somatosensory cortex (LSC), that is, the
Tracy A Glauser et al.
Epilepsia, 54(1), 141-155 (2012-11-22)
Determine the optimal initial monotherapy for children with newly diagnosed childhood absence epilepsy (CAE) based on 12 months of double-blind therapy. A double-blind, randomized controlled clinical trial compared the efficacy, tolerability, and neuropsychological effects of ethosuximide, valproic acid, and lamotrigine

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