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质量水平
方案
≥95% (HPLC)
表单
liquid
浓度
1 mg/mL in methyl acetate
运输
wet ice
储存温度
−20°C
SMILES字符串
CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O
InChI
1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1
InChI key
VHRUMKCAEVRUBK-GODQJPCRSA-N
一般描述
15-脱氧-Δ12，14-前列腺素J2（15d-PGJ2）是前列腺素J2（PGJ2）的代谢产物，是前列腺素D2的天然衍生物。它是在炎症过程中产生的。
应用
15-脱氧-Δ12，14-前列腺素J2已用于：
- 研究其对血管化脂肪组织模型中的脂质积累、活率/线粒体活性和脉管系统数量的效应
- 氧化物酶体增殖物激活受体（PPARγ）激动剂激活肠道脂肪酸结合蛋白（I-FABP）-PPARγ途径
- 作为培养培养基中的补充剂，用于诱导神经干细胞/祖细胞（NSPCs）分化
生化/生理作用
15-脱氧-Δ12，14-前列腺素J2（15d-PGJ2）调节体内炎症反应。15d-PGJ2还引起核因子（NF）-κB依赖性转录的PPARγ依赖性抑制。它作为抗血管生成的因子，并触发内皮细胞凋亡。
PPARγ（过氧化物酶体增殖物激活受体）的选择性激动剂。 抑制表达PPARγ和环氧合酶-2（COX-2）的癌细胞系的增殖。
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
靶器官
Central nervous system
补充剂危害
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
15.8 °F - closed cup
闪点(°C)
-9 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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