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Merck

D7911

Sigma-Aldrich

癸基泛醌

≥97% (HPLC)

别名:

2,3-二甲氧基-5-甲基-6-癸基-1,4-苯醌

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About This Item

经验公式(希尔记法):
C19H30O4
CAS号:
分子量:
322.44
MDL號碼:
分類程式碼代碼:
12162212
PubChem物質ID:
NACRES:
NA.25

品質等級

化驗

≥97% (HPLC)

形狀

liquid

儲存溫度

−20°C

SMILES 字串

CCCCCCCCCCC1=C(C)C(=O)C(OC)=C(OC)C1=O

InChI

1S/C19H30O4/c1-5-6-7-8-9-10-11-12-13-15-14(2)16(20)18(22-3)19(23-4)17(15)21/h5-13H2,1-4H3

InChI 密鑰

VMEGFMNVSYVVOM-UHFFFAOYSA-N

一般說明

泛醌类似物。
线粒体通透性转换孔 (MPTP) 抑制剂。

應用


  • 作为钯诱导脂肪毒性中介物的溶酶体钙(2+)。: 该研究探索了癸基泛醌(decylubiquinone)在调节溶酶体钙(2+)水平中的作用,提供了有关脂肪毒性机制和代谢疾病潜在治疗应用的见解(Oh et al., 2023)。

  • VI型硫化物中的醌结合位点:醌氧化还原酶。:该论文研究了癸基泛醌在硫化物:醌氧化还原酶中的结合动力学,阐明了其在微生物呼吸中的作用和潜在生物技术应用(Miklovics et al., 2022)。

  • 癸基泛醌对B16F10诱导小鼠中继发性黑色素瘤的保护作用。: 该研究展示了癸基泛醌在黑色素瘤小鼠模型中的抗转移性质,重点介绍了其成为癌症治疗中治疗药的潜力(Chatterjee et al., 2023)。

  • 癸基泛醌通过上调Sirtuin2来抑制结肠直肠癌细胞生长。: 该研究确认了癸基泛醌是通过调节Sirtuin2表达,而成为结肠直肠癌细胞生长的抑制剂,研究暗示了其在癌症治疗中的应用(Li et al., 2021)。

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Hongzhi Li et al.
Biochimica et biophysica acta, 1863(9), 2266-2273 (2017-06-01)
Our previous study generated a series of cybrids containing mitochondria of synaptosomes from mice at different ages. The following functional analysis on these cybrids revealed an age-dependent decline of mitochondrial function. To understand the underlying mechanisms that contribute to the
Yasser Ahmed Mahmmoud et al.
The Journal of biological chemistry, 280(30), 27776-27782 (2005-05-28)
FXYD domain-containing proteins are tissue-specific regulators of the Na,K-ATPase that have been shown to have significant physiological implications. Information about the sites of interaction between some FXYD proteins and subunits of the Na,K-ATPase is beginning to emerge. We previously identified
Klaudia Borysiuk et al.
Frontiers in plant science, 9, 667-667 (2018-06-09)
Nitrate (NO3-) and ammonium (NH4+) are prevalent nitrogen (N) sources for plants. Although NH4+ should be the preferred form of N from the energetic point of view, ammonium nutrition often exhibits adverse effects on plant physiological functions and induces an
Hannah R Bridges et al.
Nature communications, 11(1), 5261-5261 (2020-10-18)
Respiratory complex I (NADH:ubiquinone oxidoreductase) captures the free energy from oxidising NADH and reducing ubiquinone to drive protons across the mitochondrial inner membrane and power oxidative phosphorylation. Recent cryo-EM analyses have produced near-complete models of the mammalian complex, but leave
Samuel S W Szeto et al.
The Journal of biological chemistry, 287(27), 22509-22520 (2012-05-11)
Succinate dehydrogenase (SDH), also known as complex II, is required for respiratory growth; it couples the oxidation of succinate to the reduction of ubiquinone. The enzyme is composed of two domains. A membrane-extrinsic catalytic domain composed of the Sdh1p and

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