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Merck

SML0936

Sigma-Aldrich

特立氟胺

≥98% (HPLC)

别名:

(Z)-2-氰基-3-羟基-N- [4-(三氟甲基)苯基]-2-丁烯酰胺, A 1726, A77-1726, A771726, HMR 1726, N-(4-三氟甲基苯基)-2-氰基-3-羟基克罗胺, SU 20, 氟酰胺

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About This Item

经验公式(希尔记法):
C12H9F3N2O2
分子量:
270.21
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 5 mg/mL, clear (warmed)

儲存溫度

−20°C

InChI

1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-

InChI 密鑰

UTNUDOFZCWSZMS-YFHOEESVSA-N

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應用

特立氟胺是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂。

生化/生理作用

特立氟胺是一种可口服的抗炎免疫调节剂。阻断二氢乳清酸脱氢酶的活性,阻止嘧啶合成及 T、B 细胞增殖和功能。特立氟胺用于治疗风湿性关节炎,最近被批准用于多发性硬化症。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Bicuspid aortic valve (BAV) is the most common congenital cardiovascular disease in general population and is frequently associated with the development of thoracic aortic aneurysm (TAA). There is no effective strategy to intervene with TAA progression due to an incomplete

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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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