C8414

Clobazam

• 别名: 7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
• 经验公式（希尔记法）: C₁₆H₁₃ClN₂O₂
• CAS号: 22316-47-8
• 分子量: 300.74
• EC號碼: 244-908-7
• MDL號碼: MFCD00079069
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24893060
• NACRES: NA.77

属性

• 形狀: powder
• 品質等級: 200
• 藥物控制: USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• SMILES 字串: CN1C(=O)CC(=O)N(c2ccccc2)c3cc(Cl)ccc13
• InChI: 1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
• InChI 密鑰: CXOXHMZGEKVPMT-UHFFFAOYSA-N
• 基因資訊: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

说明

一般說明

Clobazam is a benzodiazepine, comprising of B ring nitrogen placed in positions 1 and 5 contrary to 1,4-benzodiazepines. It is a ligand for γ-aminobutyric acid type A (GABAA) receptor and is metabolized by cytochrome P450 in the liver.

應用

Clobazam has been used as a benzodiazepine to test its effect on the activation of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR).

生化／生理作用

Anxiolytic; ligand for the GABA_A receptor benzodiazepine modulatory site.

Clobazam interacts at α and γ2 subunits junction of the GABAA receptor. It is less sedative and elicits anxiolytic and anticonvulsant effects. Clobazam is more selective on the α2 subunit of the GABAA receptor than the α1 subunit. It is an antiseizure drug and is associated with antiepileptic activity. Clobazam is useful in treating chronic epileptic encephalopathy disorder, Lennox‐Gastaut syndrome. It is employed in epilepsy and seizure prevention adjunctive therapy.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H336,H412
• 防範說明: P261 - P264 - P270 - P271 - P273 - P301 + P312
• 危險分類: Acute Tox. 4 Oral - Aquatic Chronic 3 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)