B8041

Biglycan from bovine articular cartilage

essentially salt-free, lyophilized powder

• MDL编号: MFCD00676525
• UNSPSC代码: 12352202
• NACRES: NA.75

属性

• 生物来源: bovine articular cartilage
• 质量水平: 200
• 表单: essentially salt-free, lyophilized powder
• 分子量: 200-350 kDa
• 包装: glass bottle of 0.5 mg
• 技术: cell culture | mammalian: suitable
• 溶解性: water: soluble ≥2.00 mg/mL, clear, colorless
• UniProt登记号: P21809
• 运输: dry ice
• 储存温度: −20°C
• 基因信息: cow ... BGN(280733)

说明

一般描述

proteoglycan consisting of a 45 kDa core protein and two chrondroitin/dermatan sulfate glycosaminoglycan chains

生化/生理作用

Biglycan interacts with collagen type I and II, fibronectin and TGF-ß. In a low ionic strength (less than 3 mM phosphate) buffer, Biglycan binds more strongly to collagen type I. At higher ionic strengths, Biglycan will instead increase the inhibition effect of TGF-ß on osteoclast proliferation at a concentration of 4-20 mg/mL. It also functions to prevent the attachment of CHO cells to fibronectin, with a 50% inhibition at 17-21 mg/mL. As an extracellular component, Biglycan binds TGF-β 1, facilitates bone mineralization and supports osteoblast differentiation thru BMP-4 binding.

组分

Biglycan is a 200-350 kDa proteoglycan consisting of a 45 kDa core protein and two chondroitin/dermatan sulfate glycosaminoglycan chains.

注意

Store this product at -20°C. Stored as supplied, this powder shows little decomposition in 3 years when stored properly.

制备说明

This product is extracted from articular cartilage, chematographically purified, dialyzed against water, and 0.2 μm filtered prior to lyophilization. Once lyophilized, this powder is essentially salt-free. The product is soluble in water at 2 mg/mL.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)