B7561

1(S),9(R)-(−)-甲基溴化荷包牡丹碱

≥98% (HPLC), solid

• 别名: (5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (1:1)
• 经验公式（希尔记法）: C₂₁H₂₀BrNO₆
• CAS号: 66016-70-4
• 分子量: 462.29
• MDL號碼: MFCD00055149
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329773298
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 顏色: white to off-white
• 溶解度: H₂O: >10 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: [Br-].C[N+]1(C)CCc2cc3OCOc3cc2[C@H]1[C@@H]4OC(=O)c5c6OCOc6ccc45
• InChI: 1S/C21H20NO6.BrH/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18-,19+;/m0./s1
• InChI 密鑰: BWXCECYGGMGBHD-GRTNUQQKSA-M

说明

應用

1(S),9(R)-(-)-Bicuculline methbromide has been used:

• as a γ-aminobutyric acid (GABAA) receptor A antagonist: in cortical neuron culture
• in artificial cerebrospinal fluid (ACSF) formature dentate granule neurons
• in hypothalamic explant cultures

生化／生理作用

1(S),9(R)-(−)-Bicuculline methbromide is a GABA_A receptor antagonist, which blocks Ca²⁺-activated potassium (SK) channels. It is the water-soluble derivative of (+)-bicuculline.

特點和優勢

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全信息

• 象形圖: GHS06,GHS09
• 訊號詞: Danger
• 危險聲明: H300,H311 + H331,H410
• 防範說明: P261 - P273 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• 危險分類: Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)