S8753

马钱子碱 盐酸盐

• 经验公式（希尔记法）: C₂₁H₂₂N₂O₂ · HCl
• CAS号: 1421-86-9
• 分子量: 370.87
• EC 号: 215-826-9
• MDL编号: MFCD00058174
• UNSPSC代码: 12352210
• PubChem化学物质编号: 24899812
• NACRES: NA.32

属性

• 质量水平: 100
• SMILES字符串: Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]
• InChI: 1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1
• InChI key: VLXYTKMPCOQKEM-ZEYGOCRCSA-N

说明

应用

Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.

生化/生理作用

惊厥剂；与 NMDA 受体无关的甘氨酸受体拮抗剂。

Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.

安全信息

• 象形图: GHS06,GHS09
• 警示用语：: Danger
• 危险声明: H300 + H330,H410
• 预防措施声明: P260 - P264 - P271 - P273 - P284 - P304 + P340 + P310
• 危险分类: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• 储存分类代码: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges