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Merck

A7793

Sigma-Aldrich

5-氨基乙酰丙酸盐 盐酸盐

BioReagent, suitable for cell culture, powder, ≥98%

别名:

δ-氨基乙酰丙酸盐 盐酸盐, 5-氨基-4-氧代戊酸 盐酸盐, 5-氨基乙酰丙酸盐 盐酸盐, ALA

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About This Item

线性分子式:
NH2CH2C(O)CH2CH2COOH · HCl
CAS号:
分子量:
167.59
Beilstein:
3690651
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.75

產品線

BioReagent

品質等級

化驗

≥98%

形狀

powder

技術

cell culture | mammalian: suitable

溶解度

H2O: 50 mg/mL

儲存溫度

−20°C

SMILES 字串

Cl[H].NCC(=O)CCC(O)=O

InChI

1S/C5H9NO3.ClH/c6-3-4(7)1-2-5(8)9;/h1-3,6H2,(H,8,9);1H

InChI 密鑰

ZLHFONARZHCSET-UHFFFAOYSA-N

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應用

5-氨基乙酰丙酸是由甘氨酸和琥珀酰 CoA 通过 ALA 合成酶形成的,是腐生素生物合成途径中的第一个化合物。5-氨基酮戊酸用于光动力治疗。该化合物可用于体外研究光动力疗法的作用。

生化/生理作用

血红素生物合成中间体。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Firas Şueki et al.
Photodiagnosis and photodynamic therapy, 27, 95-99 (2019-05-18)
Photodynamic Therapy (PDT) is a promising antitumor and anti-bacterial treatment method for its high selectivity, non-invasiveness, and minimal side effects. However, cellular mechanisms may lead to PDT resistance and thus effect efficacy. The aim of this study is to test
J D Bastian et al.
Osteoarthritis and cartilage, 17(4), 539-546 (2008-10-08)
Outcome in osteochondral allografting is limited by the immunological incompatibility of the grafted tissue. Based on a resistance of chondrocytes to photodynamic therapy in cell culture it is proposed that 5-aminolevulinic acid-based photodynamic therapy (5-ALA-PDT) might be used to inactivate
Ruiqi Liao et al.
Cell reports, 31(13), 107832-107832 (2020-07-02)
Protein ensembles control genome function by establishing, maintaining, and deconstructing cell-type-specific chromosomal landscapes. A plethora of small molecules orchestrate cellular functions and therefore may link physiological processes with genome biology. The metabolic enzyme and hemoglobin cofactor heme induces proteolysis of
J P Golding et al.
Veterinary and comparative oncology, 15(4), 1543-1552 (2017-01-28)
Photodynamic therapy (PDT) holds great promise in treating veterinary and human dermatological neoplasms, including equine sarcoids, but is currently hindered by the amount of photosensitiser and light that can be delivered to lesions thicker than around 2 mm, and by the
N Neittaanmäki-Perttu et al.
The British journal of dermatology, 171(5), 1172-1180 (2014-08-12)
Daylight-mediated photodynamic therapy (DL-PDT) using methyl-5-aminolaevulinate (MAL) is effective for thin, grade I, actinic keratoses (AK). There are no published studies of other photosensitizers used in DL-PDT. To compare the efficacy and adverse effects of 5-aminolaevulinic acid nanoemulsion (BF-200 ALA)

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