A7232

AP-18

≥98% (HPLC), solid

• 别名: 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
• 经验公式（希尔记法）: C₁₁H₁₂ClNO
• CAS号: 55224-94-7
• 分子量: 209.67
• MDL號碼: MFCD00102250
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329770922
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 顏色: white to off-white
• 溶解度: DMSO: >10 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: CC(=C/c1ccc(Cl)cc1)\C(C)=N\O
• InChI: 1S/C11H12ClNO/c1-8(9(2)13-14)7-10-3-5-11(12)6-4-10/h3-7,14H,1-2H3/b8-7+,13-9+
• InChI 密鑰: MHTJEUOFLVQMCL-NJHPPEEMSA-N

说明

應用

AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice

生化／生理作用

AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves