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Merck
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SML0143

Sigma-Aldrich

HC-067047

≥98% (HPLC)

别名:

2-甲基-1-[3-（4-吗啉基）丙基]-5-苯基-N- [3-（三氟甲基）苯基]-1H-吡咯-3-甲酰胺

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About This Item

经验公式（希尔记法）:
C26H28F3N3O2
CAS号:
883031-03-6
分子量:
471.51
MDL號碼:
MFCD01571257
分類程式碼代碼:
12352200
PubChem物質ID:
329825191
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to tan

溶解度

DMSO: ≥15 mg/mL

儲存溫度

2-8°C

SMILES 字串

CC1=C(C(NC2=CC(C(F)(F)F)=CC=C2)=O)C=C(C3=CC=CC=C3)N1CCCN4CCOCC4

InChI

1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)

InChI 密鑰

NCZYSQOTAYFTNM-UHFFFAOYSA-N

應用

HC-067047 已作为瞬时受体电位阳离子通道亚家族 V 成员 4 (TRPV4) 的抑制剂，用于：
  • 研究其对人子宫内膜组织中类器官形成和增殖的影响
  • 确定其对脑出血 (ICH) 后神经元存活的影响
  • 研究其对 TRPV4 对血管紧张素 II 受体 1 型 (AT1R) 的磷酸化和β-抑制蛋白在脉络丛中募集的影响

生化／生理作用

HC-067047 是一种有效的选择性 hTRPV4 抑制剂。该化合物抑制人、大鼠和小鼠 TRPV4，IC50 值分别为 48、133 和 17nM。Hc-067047 在浓度高达 5 μM 时不抑制其他 TRPV 同种型。HC-067047 抑制 hERG 通道和薄荷醇受体 TRPM8，IC50 值分别为 370 和 780 nM。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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