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Merck
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文件

A0230

Sigma-Aldrich

Angiotensin IV trifluoroacetate salt

≥95% (HPLC), powder

别名:

Ang IV, Angiotensin II (3-8)

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About This Item

经验公式（希尔记法）:
C40H54N8O8 · xC2HF3O2
CAS号:
12676-15-2
分子量:
774.91 (free base basis)
MDL號碼:
MFCD00167496
分類程式碼代碼:
12352200
PubChem物質ID:
329770587
NACRES:
NA.77

化驗

≥95% (HPLC)

形狀

powder

顏色

white

溶解度

H2O: ~1 mg/mL

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C40H54N8O8/c1-5-24(4)34(47-35(50)29(44-37(52)33(41)23(2)3)18-26-13-15-28(49)16-14-26)38(53)45-30(20-27-21-42-22-43-27)39(54)48-17-9-12-32(48)36(51)46-31(40(55)56)19-25-10-7-6-8-11-25/h6-8,10-11,13-16,21-24,29-34,49H,5,9,12,17-20,41H2,1-4H3,(H,42,43)(H,44,52)(H,45,53)(H,46,51)(H,47,50)(H,55,56)/t24-,29-,30-,31-,32-,33-,34-/m0/s1

InChI 密鑰

QSBGWDDCOJYQGY-KOQODJNWSA-N

Amino Acid Sequence

Val-Tyr-Ile-His-Pro-Phe

生化／生理作用

AT4 angiotensin receptor agonist. The AT4 receptor appears to be important in synaptic plasticity and thus in learning and memory.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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T Kono et al.
Acta endocrinologica, 109(2), 249-253 (1985-06-01)
Studies were conducted to determine whether or not angiotensin III [AIII] and angiotensin II-(3-8)-hexapeptide [ANG-(3-8)] have their own specific arteriolar binding sites different from angiotensin II [AII] binding site(s) in man. Four patients with Bartter's syndrome were given asn1-,val5-AII by
Vanesa Esteban et al.
Circulation research, 96(9), 965-973 (2005-04-16)
Inflammation is a key event in the development of atherosclerosis. Nuclear factor-kappaB (NF-kappaB) is important in the inflammatory response regulation. The effector peptide of the renin angiotensin system Angiotensin II (Ang II) activates NF-kappaB and upregulates some related proinflammatory genes.
Z Hoły et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 43(2), 183-192 (1992-06-01)
In this work we compared in rats the influence of heptapeptide 1-7-angiotensin II, hexapeptide 2-7-angiotensin II, pentapeptide 3-7-angiotensin II and angiotensin II on motility, stereotypy, learning of conditioned avoidance responses and recall of passive avoidance behaviour allowing to avoid aversive
Anthony Lloyd Albiston et al.
Biological & pharmaceutical bulletin, 27(6), 765-767 (2004-06-10)
The angiotensin AT(4) receptor was originally defined as the specific, high affinity binding site for the hexapeptide angiotensin IV (Ang IV). Subsequently, the peptide LVV-hemorphin 7 was also demonstrated to be a bioactive ligand of the AT(4) receptor. Central administration
J J Braszko et al.
Neuroscience, 27(3), 777-783 (1988-12-01)
Angiotensin II-(3-8)-hexapeptide, at the dose of 1 nmol given intracerebroventricularly, only slightly less than angiotensin II (the same dose and route) stimulated exploratory locomotor behaviour in an open field and electromagnetic motimeter. Both peptides considerably enhanced stereotyped behaviour produced by
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