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57400

Sigma-Aldrich

吲哚-3-丙酸

≥99.0% (T)

别名:

3-（3-吲哚基）丙酸, IPA, NSC 3252, NSC 47831

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About This Item

经验公式（希尔记法）:
C11H11NO2
CAS号:
830-96-6
分子量:
189.21
Beilstein:
147733
EC 号:
212-600-1
MDL编号:
MFCD00005660
UNSPSC代码:
12352106
PubChem化学物质编号:
57651622
NACRES:
NA.77
价格与库存信息目前不能提供

质量水平

200

方案

≥99.0% (T)

表单

solid

灼烧残渣

≤0.1%

mp

~133 °C

SMILES字符串

OC(=O)CCc1c[nH]c2ccccc12

InChI

1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14)

InChI key

GOLXRNDWAUTYKT-UHFFFAOYSA-N

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相关类别

应用


  • 阐明吲哚-3-丙酸和小牛胸腺DNA的相互作用：多光谱和计算建模方法。: 该研究利用多光谱技术和计算建模，考察了吲哚-3-丙酸和小牛胸腺DNA之间的结合相互作用。由此获得的见解可以让我们更深入地了解该化合物对DNA完整性保护作用的分子机制，这对新治疗策略的开发很关键（Wei Y et al., 2024）。

  • 色氨酸代谢产物吲哚-3-丙酸提高大鼠体内脑犬尿酸水平。 : 该研究显示了色氨酸代谢产物吲哚-3-丙酸提高脑犬尿酸水平的方式，对神经保护策略和精神疾病研究具有潜在的益处。该发现彰显了该研究对精神健康研究和治疗应用的重大影响（Sathyasaikumar KV et al., 2024）。

  • 来源于血清的牛免疫球蛋白促进24位成年人的体外屏障完整性并减少炎症。: 该研究探索了吲哚-3-丙酸影响炎症反应和肠道屏障的方式，为旨在减少胃肠疾病和改善整体肠道健康的营养科学和临床应用提供了宝贵数据（Van den Abbeele P et al., 2024）。

  • 二型抗性淀粉和吲哚-3-丙酸改善高脂肪饮食引起的肝脂肪变性和肠道生态失调。: 该论文讨论了吲哚-3-丙酸与二型抗性淀粉在减轻高脂肪膳食引起的肝脂肪变性和纠正肠道生态失调中的作用，目的在于肥胖症和相关代谢疾病管理中的潜在膳食干预（Yang M et al., 2024）。

  • HIV患者中的肠道微生物组和心血管代谢合并症。: 该综述重点介绍了吲哚-3-丙酸在肠道微生物组调节中的作用，及其在HIV阳性患者心血管代谢健康中的潜在作用。该研究发现显示了一条通过微生物组干预改善患者群体生活质量和健康状况的可能途径（Trøseid M et al., 2024）。

生化/生理作用

被研究作为改善肝移植后灌注的辅助手段。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL6181
BCCJ3021
039038/2
039038/1
307547/2

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Zhongqi Cheng et al.
Environmental science & technology, 39(19), 7662-7666 (2005-10-26)
Field and laboratory experiments were conducted to study the potential use of Fe filings to remove monomethyl arsenate (MMA) and dimethyl arsenate (DMA) from contaminated waters. Batch experiments show that the affinity of MMAfor Fe filings is comparable to that
K L Borden et al.
European journal of biochemistry, 202(2), 459-470 (1991-12-05)
The antirepressor indole 3-propanoate has been shown by X-ray crystallography to bind in a different orientation compared with the natural corepressor for the tryp repressor, L-tryptophan (Lawson, C.L. & Sigler, P. B. (1988) Nature 333, 869-871). This suggests a simple
R Hardeland et al.
Advances in experimental medicine and biology, 467, 389-395 (2000-03-18)
Chemiluminescence associated with oxidation by free radicals was investigated in an alkaline, hemin-catalysed hydrogen peroxide system, using the following tryptophan metabolites as radical scavengers: indole-3-pyruvic, indole-3-propionic, kynurenic, xanthurenic and quinaldic acids and 4-hydroxy-quinoline. Light emission from oxidation of the indolic
Paul E Bendheim et al.
Journal of molecular neuroscience : MN, 19(1-2), 213-217 (2002-09-06)
The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and
Qiaomei Lu et al.
Rapid communications in mass spectrometry : RCM, 22(16), 2565-2572 (2008-07-26)
Auxin is an important phylohormone, which regulates specific physiological responses such as division, elongation and differentiation of cells. A new method using liquid chromatography/electrospray ionization ion trap mass spectrometry (LC/ESI-ITMS) has been developed for identification and quantitation of four auxins.
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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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