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Merck
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53886

Sigma-Aldrich

Tn Antigen

≥99.0% (TLC), powder or crystals

别名:

, GalNac-α-1-O-serine

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About This Item

经验公式（希尔记法）:
C11H20N2O8
CAS号:
67262-86-6
分子量:
308.29
MDL编号:
MFCD01863462
UNSPSC代码:
12352204
PubChem化学物质编号:
329758013
NACRES:
NA.32

产品名称

Tn Antigen, ≥99.0% (TLC)

方案

≥99.0% (TLC)

表单

powder or crystals

储存温度

−20°C

SMILES字符串

CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@H](N)C(O)=O

InChI

1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1

InChI key

REDMNGDGDYFZRE-WKWISIMFSA-N

相关类别

一般描述

Tn 抗原是一种截短的 O -聚糖，在结直肠癌（CRC）中常见。通常在癌细胞中高水平表达。Tn 抗原体积小，结构简单。其在人体内具有非生理性聚糖结构，因此可能被免疫系统识别为异物。

生化/生理作用

Tn 抗原通过 H-Ras 介导的上皮间质转换刺激结直肠癌转移。作为几种重要复合物 O -聚糖的前体。携带 Tn 抗原的所有谱系中的血细胞亚群导致一种称为 Tn 综合征的血液疾病。

包装

无底玻璃瓶。内含物装在插入式熔锥内。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM3173
BCCL4481
BCCK7363
BCCL1898
BCCJ0446

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Yasuyuki Matsumoto et al.
Glycobiology, 30(5), 282-300 (2019-11-20)
The Tn antigen is a neoantigen abnormally expressed in many human carcinomas and expression correlates with metastasis and poor survival. To explore its biomarker potential, new antibodies are needed that specifically recognize this antigen in tumors. Here we generated two
Neha M Sahasrabudhe et al.
Biological chemistry, 399(7), 649-659 (2018-06-13)
Colorectal cancer is the third most common cancer type worldwide. It is characterized by a high expression of aberrantly glycosylated ligands, such as the Tn antigen (GalNAcα1-Ser/Thr), which is a major ligand for the C-type lectin macrophage galactose-type lectin (MGL).
Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation
Liu Z, et al.
Journal of Cellular and Molecular Medicine (2019)
Xichen Dong et al.
BioMed research international, 2018, 9532389-9532389 (2018-07-24)
Immature truncated O-glycans such as Tn antigen are frequently detected in human colorectal cancer (CRC); however, the precise pathological consequences of Tn antigen expression on CRC are unknown. T-synthase is the key enzyme required for biosynthesis of mature O-glycans. Here
Ting-Chun Kuo et al.
Oncogene, 40(7), 1242-1254 (2021-01-10)
Pancreatic adenocarcinoma (PDAC) is a leading cause of cancer-related death. Altered glycosylation contributes to tumor progression and chemoresistance in many cancers. C1GALT1 is the key enzyme controlling the elongation of GalNAc-type O-glycosylation. Here we showed that C1GALT1 was overexpressed in
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