The linear formula for hyaluronic acid sodium salt is [C14H22NNaO11]n where n is the number of monomeric units present in the polymer. This would equate to 403.31 g/mol for each unit. Hyaluronic acid has the linear formula [C16H27NO11]n which would have a molecular weight of 409.39 per unit.
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生物来源
(Streptococcus equi)
质量水平
表单
powder or crystals
分子量
~1.5-1.8 x 10E6 Da
杂质
≤1% protein
颜色
white
溶解性
H2O: 5 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
[Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2C([O-])=O
InChI
1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
InChI key
YWIVKILSMZOHHF-QJZPQSOGSA-N
一般描述
透明质酸（HA）是中枢神经系统细胞外基质的重要组分，是在所有脊椎动物结缔组织中都能发现的多功能大分子。这种超分子糖胺聚糖是一种聚阴离子天然聚合物，以线性多糖的形式存在。它由葡萄糖醛酸和N-乙酰氨基葡萄糖通过β-1,4键重复组成。透明质酸在眼睛、关节和心脏瓣膜中大量存在。
应用
马链球菌透明质酸钠盐已用于：
- 与甲基丙烯酸酐合成交联甲基丙烯酸 HA 水凝胶（Coll-MeHA）
- 在磷酸盐缓冲盐水（PBS）中取代 PBS 浴槽来改变润滑剂成分
- 制备润滑剂，以研究对人体骨关节炎（OA）软骨边界润滑的影响
生化/生理作用
透明质酸（HA）是滑膜液和关节软骨的重要组分，起边界润滑剂的作用。它具有多种物理化学性质，包括生物可降解性、生物相容性、无毒性和非免疫原性。透明质酸被认为是生物医学用途的重要工具，如药物输送、组织工程、整形外科、眼科手术和骨关节炎手术。它参与身体缓冲和润滑。这种强大的抗氧化剂可以将水与组织结合。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
其他客户在看
Jae-Yong Park et al.
PloS one, 9(11), e112684-e112684 (2014-11-27)
Synovial fluid plays an important role in lubricating synovial joints. Its main constituents are hyaluronic acid (HA) and γ-globulin, acting as boundary lubricants for articular cartilage. The aim of the study was to demonstrate the concentration-dependent effect of HA and
Telma E Santos et al.
Cell reports, 32(3), 107907-107907 (2020-07-23)
During development of the central nervous system (CNS), neurons polarize and rapidly extend their axons to assemble neuronal circuits. The growth cone leads the axon to its target and drives axon growth. Here, we explored the mechanisms underlying axon growth
Wei-Yao Chen et al.
Frontiers in endocrinology, 12, 572690-572690 (2021-03-30)
The global obesity population is increasing year-by-year, and the related cost is sharply increasing annually. There are several methods available to combat obesity; however, there is a lack of a single tool that is both safe and efficacious. The use
H C Lin et al.
European cells & materials, 40, 133-145 (2020-09-21)
Vascularisation efficiency plays an essential role in the success of bulk transplantation, while biocompatibility and safety are major concerns in clinical applications. Fibrin-based hydrogels have been exploited as scaffolds for their advantages in biocompatibility, degradability and mass transportation in various
Tao Jin et al.
Biomaterials, 113, 176-190 (2016-11-07)
Extracellular matrix (ECM) is widely used as an inductive biological scaffold to repair soft tissue after injury by promoting functional site-appropriate remodeling of the implanted material. However, there is a lack of non-invasive analysis methods to monitor the remodeling characteristics
商品
有五种已发现的糖胺聚糖链（参见图1）透明质酸不是硫酸化的，但其他糖胺聚糖链在链的不同位置含有硫酸根取代基。
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
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May I know the formula and MW for one unit of Hyaluronic acid? And I also need the formula and MW for one unit of Hyaluronic acid Sodium. Thanks!
1 answer-
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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Is this suitable for sterile use or should it be sterilized and how would you recommend to sterilize?
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TS Answer: This product is not sterile, however, prepared stock solutions may be autoclaved or filter-sterilized. The estimated molecular weight range is 0.85 to 1.6 million daltons. Filtration studies of high molecular weight HA have not been performed, however, various literature sources suggest the use of a PES filter membrane would be the best option. There are a number of product alternatives available, such as the Steriflip-GP product SCGP00525 - see the link below to review this product.
https://www.sigmaaldrich.com/US/en/product/mm/scgp00525
Alternatively, HA can be added directly to the medium prior to filtration for tissue culture applications. See the link below to review a publication demonstrating this process:
https://pubmed.ncbi.nlm.nih.gov/35907556/Helpful?
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How should product 53747 be stored after it is resuspended in solution?
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Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
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What is the molecular weight of this hyaluronic acid, in units of g/mol?
1 answer-
The molecular weight of this product, based on viscosity, generally ranges from 1.3 - 1.8 MDa, but can be as high as 2.5 MDa.
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このヒアルロン酸を水に溶かして1mg/mLの溶液を作製しました。摩ル濃度（mol/L）を計算するにはどうすればよいですか？
1 answer-
The molecular weight of this product, based on viscosity, generally ranges from 1.3 - 1.8 MDa, but can be as high as 2.5 MDa. At a concentration of 1 mg/ml the molarity may be in the range of 6.6-5.5 X 10E-7 mol/L. This is only an estimation due to the variable molecular weight.
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How should I store Product 53747, Hyaluronic acid sodium salt from Streptococcus equi?
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This product should be stored at - 20 °C.
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What is the molecular weight of Product 53747, Hyaluronic acid sodium salt from Streptococcus equi?
1 answer-
According to our supplier, the molecular weight of Product 53747 is approximately 1.5 to 1.8 X 10E6 Dalton.
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Can Product 53747, Hyaluronic acid, be sterilized?
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Yes, according to references you can autoclave Hyaluronic acid sodium salt from Streptococcus equi.
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