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Merck

161527

Sigma-Aldrich

硫氢化钠 水合物

Sodium hydrosulfide hydrate
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About This Item

线性分子式:
NaSH·xH2O
分子量:
56.06 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352302
PubChem化学物质编号:
NACRES:
NA.55
表单:
chips
flakes
价格与库存信息目前不能提供

表单

chips
flakes

质量水平

浓度

≥60% (by Na2S2O3, titration)

mp

52-54 °C (lit.)

SMILES字符串

[Na]S.[H]O[H]

InChI

1S/Na.H2O.H2S/h;2*1H2/q+1;;/p-1

InChI key

ZNKXTIAQRUWLRL-UHFFFAOYSA-M

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一般描述

氢硫化钠水合物是钠的水合无机盐。它参与合成(E)-2-氰基-2-(噻唑烷-2-亚基)硫代乙酰胺。[1]

应用

它可以用作硫亲核试剂以诱导α,β-二氯乙烯基酮中的CS键形成,以形成5-至8-元环状硫醚。[2]
氢硫化钠水合物可用于以下合成:
  • 苯并噻唑[3]
  • 4-甲氧基苯并硫代酰胺[4]
  • 2-(4-甲氧基苯基)咪唑啉[3]
  • 7-氯-4′-甲氧基硫黄酮[5]

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral - Aquatic Acute 1 - Skin Corr. 1B

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

194.0 °F - closed cup

闪点(°C)

90 °C - closed cup


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Zili Zhang et al.
Life sciences, 232, 116650-116650 (2019-07-16)
Inhalation of NO2 leads to a progressive airflow limitation and the development of emphysema-like lesions. We report on the efficacy of hydrogen sulfide (NaHS) for alleviating NO2-induced pulmonary impairment. Sprague Dawley rats were exposed to 20 ppm NO2 for 6 h over
Honggang Wang et al.
Biology open, 8(7) (2019-07-19)
The aim of this study was to investigate whether exogenous hydrogen sulfide (H2S) could mitigate NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway in L02 cells. L02 cells were stimulated with different concentrations of oleic acid (OA), then
Synthesis of Benzothiazoles through Copper-Catalyzed One-Pot Three-Component Reactions with Use of Sodium Hydrosulfide as a Sulfur Surrogate.
Park N, et al.
European Journal of Organic Chemistry, 10, 1984-1993 (2012)
Min Sun et al.
European journal of medicinal chemistry, 45(6), 2299-2306 (2010-02-26)
Two series of novel diaryl ureas have been designed and synthesized, with their in vitro antitumor effect screened on human non-small cell lung cancer (NSCLC) cell line A549 and human breast cancer cell line MDA-MB-231. Some target compounds demonstrated significant
Practical and Versatile Synthesis of Thioflavones from 2-Bromobenzoyl Chlorides.
Lee JI and Choi JS.
J. Korean Chem. Soc., 59(3) (2015)

Questions

1–8 of 8 Questions  
  1. Which storage conditions do you recommend once the product is diluted (for short- and long-term storage)? 

    1 answer
    1. Solubility and solution stability are not tested internally, but literature and other suppliers indicate that when stored at -80°C, the stock solution should be used within 6 months, and when stored at -20°C, it should be used within 1 month. However, due to the lack of internal testing, this cannot be guaranteed.

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  4. Can the waters of hydration be removed in vacuo or with a dessicant, or will the NaSH decompose without the waters of hydration?

    1 answer
    1. A desiccant may not be effective in the removal of the water of hydration. There is binding energy between the anhydrous material and water; it is unknown if any water of hydration can be removed using a desiccant alone. Heating under vacuum may be an option, however the temperature would have to be validated empirically. A brief search of the literature reveals some discussion regarding this matter and the use of dry solvents with activated molecular sieves at the ResearchGate website. See the link below to review:
      https://www.researchgate.net/post/Drying-Hydrates-over-activated-Molecular-Sieves

      Helpful?

  5. What is the sodium hydrosulfide (NaHS) content for Product 161527, Sodium hydrosulfide hydate?

    1 answer
    1. The NaHS content of this product is typically about 70%. The value for each lot is reported on the Certifcate of Analysis (CofA).

      Helpful?

  6. What is the typical water content of Product 161527, Sodium hydrosulfide hydate? That is, how many waters of hydration?

    1 answer
    1. Product No. 161527 is typically a sesquihydrate, meaning 1.5 moles of water per mole of NaHS.

      Helpful?

  7. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  8. What are the impurities in Product 161527, Sodium hydrosulfide hydate?

    1 answer
    1. The impurities are sodium sulfide, water, sodium sulfoxide, sodium carbonate and iron.

      Helpful?

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