V8388

长春新碱 硫酸酯

meets USP testing specifications

• 别名: 长春新碱 硫酸盐, VCR, 醛基长春碱 硫酸盐, 长春醛碱 硫酸盐
• 经验公式（希尔记法）: C₄₆H₅₆N₄O₁₀ · H₂SO₄
• CAS号: 2068-78-2
• 分子量: 923.04
• Beilstein: 3924631
• EC號碼: 218-190-0
• MDL號碼: MFCD00084729
• 分類程式碼代碼: 12352210
• PubChem物質ID: 24900771
• NACRES: NA.21

属性

• agency: USP/NF; meets USP testing specifications
• 品質等級: 200
• 溶解度: ethanol: slightly soluble; methanol: soluble; water: freely soluble
• 抗生素活性譜: neoplastics
• 應用: pharmaceutical (small molecule)
• 作用方式: protein synthesis | interferes
• 儲存溫度: −20°C
• SMILES 字串: OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
• InChI: 1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
• InChI 密鑰: AQTQHPDCURKLKT-PNYVAJAMSA-N

说明

一般說明

Vincristine sulfate is an alkaloid present in Cantharanthus roseus.

應用

use product name over-ride for USP name - jk 6/2/2005

Vincristine sulfate has been used:

• as a positive control in potato disc anti-tumor bioassay
• as a standard cytotoxic agent
• to treat cells for manipulation of the microtubule network

生化／生理作用

Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.

安全信息

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H300,H341,H361fd
• 防範說明: P202 - P264 - P270 - P280 - P301 + P310 - P405
• 危險分類: Acute Tox. 2 Oral - Muta. 2 - Repr. 2
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)