跳转至内容
Merck

PHR1866

Supelco

依折麦布

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

依泽替米贝, (3R,4S)-1-(4-氟苯基)-3-[(S)-3-(4-氟苯基)-3-羟基丙基]-4-(4-羟基苯基)-2-氮杂环丁酮

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C24H21F2NO3
分子量:
409.43
MDL编号:
UNSPSC代码:
41116107
NACRES:
NA.24
价格与库存信息目前不能提供

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1269028

API类

ezetimibe

表单

powder

CofA

current certificate can be downloaded

包装

pkg of 1 g

应用

pharmaceutical

储存温度

2-8°C

SMILES字符串

FC(C=C1)=CC=C1N([C@H](C2=CC=C(O)C=C2)[C@H]3CC[C@H](O)C4=CC=C(F)C=C4)C3=O

InChI

1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1

InChI key

OLNTVTPDXPETLC-XPWALMASSA-N

正在寻找类似产品? 访问 产品对比指南

一般描述

该认证标准物质(CRM)根据ISO 17034和ISO/IEC 17025生产和认证。有关该CRM使用的所有信息可见于分析证书。

用于质量控制的药品二级标准品,为制药实验室和制造商提供了一种方便且经济的替代方案,可用于内部工作标准品的制备。

依泽替米贝属于2-氮杂环丁酮胆固醇吸附抑制剂类。它选择性阻断膳食和胆汁来源中胆固醇的吸收,因此阻止了胆固醇通过肠壁的转运。

应用

该药物二级标准品也用于以下应用:
  • 开发用于测定散装和药物制剂中的依泽替米贝的两种分光光度法 [1]
  • 通过毛细管电泳(CE)分离和测定片剂中的依泽替米贝和阿托伐他汀
  • 通过按照ICH 指南确认的稳定性指示性反相高效液相色谱(RP-HPLC)同时估计复方片剂中的缬沙坦和 依泽替米贝[2]
  • 通过RP-HPLC 方法进行药物制剂中罗苏伐他汀、替米沙坦、依泽替米贝和阿托伐他汀的多重分析[3]
  • 通过分光光度法和TLC-密度测定法定量分析药物制剂中的依泽替米贝和阿托伐他汀钙。

分析说明

这些二级标准品可追溯至USP、EP和BP一级标准品。

附注

想要查看本品的检验报告示例,请在下框中输入LRAC1517。这只是一个示例证书,可能与您收到的批次不符。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 文件 section.

如需帮助,请联系 客户支持

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Stability-indicating HPLC method for the simultaneous determination of valsartan and ezetimibe in Pharmaceuticals
Ramachandran S, et al.
Tropical Journal of Pharmaceutical Research, 13, 809-817 (2014)
Spectrophotometric determination of ezetimibe
Lakshmi P, et al.
E-Journal of Chemistry, 7, 101-104 (2010)
Chemometric technique for the optimization of chromatographic system: Simultaneous HPLC determination of Rosuvastatin, Telmisartan, Ezetimibe and Atorvastatin used in combined cardiovascular therapy
Janardhanan VS, et al.
Arabian Journal of Chemistry, 9, S1378-S1387 (2016)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

Reviews

No rating value

Active Filters

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门